| Tag | Content |
|---|
| CPLM ID | CPLM-001563 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
Protein Synonyms/Alias | HsPDE8B; Cell proliferation-inducing gene 22 protein |
Gene Name | PDE8B |
Gene Synonyms/Alias | PIG22 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 495 | YSPQLGTKDEDPHTS | ubiquitination | [1] | | 745 | KFVNSINKPMAAEIE | ubiquitination | [1] | | 811 | FAQTDEEKRQGLPVV | ubiquitination | [1] |
|
Reference | [1] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] |
Functional Description | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. |
Sequence Annotation | DOMAIN 267 338 PAS.
REGION 590 868 Catalytic (By similarity).
ACT_SITE 615 615 Proton donor (By similarity).
METAL 619 619 Divalent metal cation 1 (By similarity).
METAL 655 655 Divalent metal cation 1 (By similarity).
METAL 656 656 Divalent metal cation 1 (By similarity).
METAL 656 656 Divalent metal cation 2 (By similarity).
METAL 781 781 Divalent metal cation 1 (By similarity).
MOD_RES 517 517 Phosphoserine. |
Keyword | Alternative splicing; cAMP; Complete proteome; Cushing syndrome; Disease mutation; Hydrolase; Metal-binding; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 885 AA |
Protein Sequence | MGCAPSIHVS QSGVIYCRDS DESSSPRQTT SVSQGPAAPL PGLFVQTDAA DAIPPSRASG 60
PPSVARVRRA RTELGSGSSA GSAAPAATTS RGRRRHCCSS AEAETQTCYT SVKQVSSAEV 120
RIGPMRLTQD PIQVLLIFAK EDSQSDGFWW ACDRAGYRCN IARTPESALE CFLDKHHEII 180
VIDHRQTQNF DAEAVCRSIR ATNPSEHTVI LAVVSRVSDD HEEASVLPLL HAGFNRRFME 240
NSSIIACYNE LIQIEHGEVR SQFKLRACNS VFTALDHCHE AIEITSDDHV IQYVNPAFER 300
MMGYHKGELL GKELADLPKS DKNRADLLDT INTCIKKGKE WQGVYYARRK SGDSIQQHVK 360
ITPVIGQGGK IRHFVSLKKL CCTTDNNKQI HKIHRDSGDN SQTEPHSFRY KNRRKESIDV 420
KSISSRGSDA PSLQNRRYPS MARIHSMTIE APITKVINII NAAQENSPVT VAEALDRVLE 480
ILRTTELYSP QLGTKDEDPH TSDLVGGLMT DGLRRLSGNE YVFTKNVHQS HSHLAMPITI 540
NDVPPCISQL LDNEESWDFN IFELEAITHK RPLVYLGLKV FSRFGVCEFL NCSETTLRAW 600
FQVIEANYHS SNAYHNSTHA ADVLHATAFF LGKERVKGSL DQLDEVAALI AATVHDVDHP 660
GRTNSFLCNA GSELAVLYND TAVLESHHTA LAFQLTVKDT KCNIFKNIDR NHYRTLRQAI 720
IDMVLATEMT KHFEHVNKFV NSINKPMAAE IEGSDCECNP AGKNFPENQI LIKRMMIKCA 780
DVANPCRPLD LCIEWAGRIS EEYFAQTDEE KRQGLPVVMP VFDRNTCSIP KSQISFIDYF 840
ITDMFDAWDA FAHLPALMQH LADNYKHWKT LDDLKCKSLR LPSDS 885 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; NAS:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro. GO:0006198; P:cAMP catabolic process; IEA:UniProtKB-UniPathway. GO:0009187; P:cyclic nucleotide metabolic process; NAS:UniProtKB. GO:0035556; P:intracellular signal transduction; IEA:GOC. GO:0046676; P:negative regulation of insulin secretion; IEA:Compara. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |