CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037855
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Fatty acyl-CoA reductase 1 
Protein Synonyms/Alias
  
Gene Name
 FAR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
11IPEYYEGKNVLLTGAubiquitination[1]
29LGKVLLEKLLRSCPKubiquitination[1, 2]
36KLLRSCPKVNSVYVLubiquitination[1, 3]
63VEEVLSGKLFDRLRDubiquitination[1, 2, 3, 4, 5, 6]
78ENPDFREKIIAINSEubiquitination[1, 4]
90NSELTQPKLALSEEDubiquitination[4, 6]
161AYAYCNRKHIDEVVYubiquitination[1, 2, 4]
176PPPVDPKKLIDSLEWubiquitination[4, 6]
208PNTYIYTKALAEYVVubiquitination[1, 2, 4, 6]
259GLFIAAGKGILRTIRubiquitination[6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 335 AA 
Protein Sequence
MVSIPEYYEG KNVLLTGATG FLGKVLLEKL LRSCPKVNSV YVLVRQKAGQ TPQERVEEVL 60
SGKLFDRLRD ENPDFREKII AINSELTQPK LALSEEDKEV IIDSTNIIFH CAATVRFNEN 120
LRDAVQLNVI ATRQLILLAQ QMKNLEVFMH VSTAYAYCNR KHIDEVVYPP PVDPKKLIDS 180
LEWMDDGLVN DITPKLIGDR PNTYIYTKAL AEYVVQQEGA KLNVAIVRPS IVGASWKEPF 240
PGWIDNFNGP SGLFIAAGKG ILRTIRASNN ALADLVPVDV VVNMSLAAAW YSGVNRPRNI 300
MVYNCTTGST NPFHWGEVGM ILPVFLNVRI NLKEP 335 
Gene Ontology
 GO:0080019; F:fatty-acyl-CoA reductase (alcohol-forming) activity; IEA:InterPro. 
Interpro
 IPR026055; FAR.
 IPR013120; Male_sterile_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF07993; NAD_binding_4 
SMART
  
PROSITE
  
PRINTS