UniProt Accession

 AKIP_HUMAN; Q9NWT8; Q5TA36; Q8TBD3 

Genbank Protein ID

 AK000615; AL139287; BC022808; BC062333 

Genbank Nucleotide ID

 BAA91289.1; CAI23191.1; AAH22808.1; AAH62333.1 

Protein Name

 Aurora kinase A-interacting protein 

Protein Synonyms/Alias

 AURKA-interacting protein 

Gene Name

 AURKAIP1 

Gene Synonyms/Alias

 AIP; AKIP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	RAASLPRKGAQLELE	ubiquitination	[1]
193	PEGWQTPKIYLRGK*	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation. 

Sequence Annotation

  

Keyword

 Complete proteome; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 199 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0045839; P:negative regulation of mitosis; NAS:UniProtKB.
 GO:0045862; P:positive regulation of proteolysis; IDA:MGI. 

Interpro

 IPR013177; DUF1713_mit. 

Pfam

 PF08213; DUF1713 

SMART

  

PROSITE

  

PRINTS