| Tag | Content |
|---|
| CPLM ID | CPLM-007935 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rabphilin-3A |
Protein Synonyms/Alias | Exophilin-1 |
Gene Name | Rph3a |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 660 | KHWYECLKNKDKKIE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. |
Sequence Annotation | DOMAIN 40 157 RabBD.
DOMAIN 381 485 C2 1.
DOMAIN 539 642 C2 2.
ZN_FING 88 145 FYVE-type.
METAL 409 409 Calcium 1; via carbonyl oxygen.
METAL 410 410 Calcium 1.
METAL 410 410 Calcium 2.
METAL 416 416 Calcium 2.
METAL 471 471 Calcium 1.
METAL 471 471 Calcium 2.
METAL 472 472 Calcium 2; via carbonyl oxygen.
METAL 473 473 Calcium 1.
METAL 473 473 Calcium 2.
METAL 479 479 Calcium 1.
METAL 526 526 Calcium 3; via carbonyl oxygen (By
METAL 568 568 Calcium 3 (By similarity).
METAL 568 568 Calcium 4 (By similarity).
METAL 574 574 Calcium 3 (By similarity).
METAL 628 628 Calcium 3 (By similarity).
METAL 628 628 Calcium 4 (By similarity).
METAL 629 629 Calcium 3; via carbonyl oxygen (By
METAL 630 630 Calcium 3 (By similarity).
METAL 630 630 Calcium 4 (By similarity).
METAL 636 636 Calcium 4 (By similarity).
MOD_RES 271 271 Phosphoserine. |
Keyword | 3D-structure; Calcium; Cell junction; Complete proteome; Lipid-binding; Membrane; Metal-binding; Phosphoprotein; Protein transport; Reference proteome; Repeat; Synapse; Transport; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 681 AA |
Protein Sequence | MTDTVVNRWM YPGDGPLQSN DKEQLQAGWS VHPGAQTDRQ RKQEELTDEE KEIINRVIAR 60
AEKMEAMEQE RIGRLVDRLE TMRKNVAGDG VNRCILCGEQ LGMLGSACVV CEDCKKNVCT 120
KCGVETSNNR PHPVWLCKIC LEQREVWKRS GAWFFKGFPK QVLPQPMPIK KTKPQQPAGE 180
PATQEQPTPE SRHPARAPAR GDMEDRRPPG QKPGPDLTSA PGRGSHGPPT RRASEARMST 240
AARDSEGWDH AHGGGTGDTS RSPAGLRRAN SVQAARPAPA PVPSPAPPQP VQPGPPGGSR 300
ATPGPGRFPE QSTEAPPSDP GYPGAVAPAR EERTGPAGGF QAAPHTAAPY SQAAPARQPP 360
PAEEEEEEAN SYDSDEATTL GALEFSLLYD QDNSNLQCTI IRAKGLKPMD SNGLADPYVK 420
LHLLPGASKS NKLRTKTLRN TRNPVWNETL QYHGITEEDM QRKTLRISVC DEDKFGHNEF 480
IGETRFSLKK LKANQRKNFN ICLERVIPMK RAGTTGSARG MALYEEEQVE RIGDIEERGK 540
ILVSLMYSTQ QGGLIVGIIR CVHLAAMDAN GYSDPFVKLW LKPDMGKKAK HKTQIKKKTL 600
NPEFNEEFFY DIKHSDLAKK SLDISVWDYD IGKSNDYIGG CQLGISAKGE RLKHWYECLK 660
NKDKKIERWH QLQNENHVSS D 681 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0008021; C:synaptic vesicle; IEA:InterPro. GO:0005509; F:calcium ion binding; ISS:UniProtKB. GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB. GO:0005215; F:transporter activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006886; P:intracellular protein transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |