UniProt Accession

 CALB1_BOVIN; P04467; Q1LZA2 

Genbank Protein ID

 BC116125 

Genbank Nucleotide ID

 AAI16126.1 

Protein Name

 Calbindin 

Protein Synonyms/Alias

 Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type 

Gene Name

 CALB1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
109	EFMKTWRKYDTDHSG	ubiquitination	[1]
124	FIETEELKNFLKDLL	ubiquitination	[1]
128	EELKNFLKDLLEKAN	ubiquitination	[1]
142	NKTVDDTKLAEYTDL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. 

Sequence Annotation

 DOMAIN 11 46 EF-hand 1.
 DOMAIN 47 82 EF-hand 2.
 DOMAIN 98 133 EF-hand 3.
 DOMAIN 142 177 EF-hand 4.
 DOMAIN 186 221 EF-hand 5.
 DOMAIN 226 251 EF-hand 6.
 REGION 2 7 Interaction with RANBP9 (By similarity).
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Calcium; Complete proteome; Direct protein sequencing; Metal-binding; Reference proteome; Repeat; Vitamin D. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005499; F:vitamin D binding; IEA:UniProtKB-KW.
 GO:0071310; P:cellular response to organic substance; IEA:Compara.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0072205; P:metanephric collecting duct development; IEA:Compara.
 GO:0072286; P:metanephric connecting tubule development; IEA:Compara.
 GO:0072221; P:metanephric distal convoluted tubule development; IEA:Compara.
 GO:0035502; P:metanephric part of ureteric bud development; IEA:Compara.
 GO:0010842; P:retina layer formation; IEA:Compara. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13202; EF_hand_3
 PF13405; EF_hand_4
 PF00036; efhand 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS