CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014773
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 
Protein Synonyms/Alias
 Isocitric dehydrogenase subunit beta; NAD(+)-specific ICDH subunit beta 
Gene Name
 Idh3B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
72HAVKEVFKAAAVPVEacetylation[1]
81AAVPVEFKEHHLSEVacetylation[1]
96QNMASEEKLEQVLSSacetylation[1]
105EQVLSSMKENKVAIIacetylation[1]
108LSSMKENKVAIIGKIacetylation[1]
122IYTPMEYKGELASYDacetylation[1]
135YDMQLRRKLDLFANVacetylation[1]
146FANVVHVKSLPGYKTacetylation[1]
152VKSLPGYKTRHNNLDacetylation[1]
199TKSQRIAKFAFDYATacetylation[1]
207FAFDYATKKGRSKVTacetylation[1]
350SMIADAVKKVIKVGKacetylation[1]
354DAVKKVIKVGKVRTRacetylation[1]
374STTTDFIKSVIGHLHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 METAL 251 251 Magnesium or manganese (By similarity).
 BINDING 133 133 Substrate (By similarity).
 BINDING 164 164 Substrate (By similarity).
 BINDING 251 251 Substrate (By similarity).
 MOD_RES 199 199 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Reference proteome; Transit peptide; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 385 AA 
Protein Sequence
MAALSNVRWL TRAVLGARNS GAWRGLRTAA SAQAASQSQA QDVRVEGAFP VTMLPGDGVG 60
PELMHAVKEV FKAAAVPVEF KEHHLSEVQN MASEEKLEQV LSSMKENKVA IIGKIYTPME 120
YKGELASYDM QLRRKLDLFA NVVHVKSLPG YKTRHNNLDL VIIREQTEGE YSSLEHESAR 180
GVIECLKIVT RTKSQRIAKF AFDYATKKGR SKVTAVHKAN IMKLGDGLFL QCCEEVAELY 240
PKIKFETMII DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY 300
AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK KVIKVGKVRT 360
RDMGGYSTTT DFIKSVIGHL HPHGG 385 
Gene Ontology
 GO:0005962; C:mitochondrial isocitrate dehydrogenase complex (NAD+); IC:RGD.
 GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IDA:RGD.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006103; P:2-oxoglutarate metabolic process; IDA:RGD.
 GO:0006102; P:isocitrate metabolic process; IDA:RGD.
 GO:0006734; P:NADH metabolic process; IDA:RGD.
 GO:0006099; P:tricarboxylic acid cycle; IDA:RGD. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR001804; Isocitrate/isopropylmalate_DH.
 IPR004434; Isocitrate_DH_NAD.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS