CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MCG18845, isoform CRA_d 
Protein Synonyms/Alias
 Protein Uba7; Ubiquitin-activating enzyme E1-like 
Gene Name
 Uba7 
Gene Synonyms/Alias
 Ube1l; mCG_18845 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
223PQSVRVQKDGSLEIGubiquitination[1]
473RQFLFRPKDVRRPKAubiquitination[1]
769WRKGPPLKPVLFVKDubiquitination[1]
808PVNHARIKQIVGRIIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 977 AA 
Protein Sequence
MDEELYSRQL YVLGLPAMQR IQEAKVLLCG LQGLGAEVAK NLVLTGVGSL TLHDPHPTCW 60
ADLAAQCFLS EESLGRNRAE ASQAQLAQLN EAVQISVHSG DITEDLLQGF QVVVLTDSKL 120
EDQLKVGPLC HKHGVRFLMA ETRGLVGRLF CDFGEDFTVL DPTEVEPMTA AIQDISQGFP 180
GIVTLRGDTK RHSFHDGDLV IFSDIEGMVE LNSCSPQSVR VQKDGSLEIG DTTTFSRYLR 240
GGVVTEVKRP KTVRHKPLDI ALLQPHVVAQ NTQEVQRAHC LHQAFHVLHK FQQLHGRLPK 300
PWDPDDAETV VELAQDLEPL KGTEEESLDE ALLRTIALSS AGTLSPMAAI MGGVAAQEVL 360
KAISRKFMPL DQWLYFDALE CLPEDETLLP SPEDCQPRNC RYDGQIAVFG TDLQEKLSDQ 420
HYLLVGAGAI GCEMLKVFAL VGLGVRANGG VTVADMDYIE RSNLSRQFLF RPKDVRRPKA 480
EVAAAAAHRL NPDLRATPYT CPLDPTTEDI YDDSFFSRVN GVVAALDSFQ ARHYVAARCT 540
HYLKPLLEAG TQGTWGSASV FVPYVTEAYR GPASDAASED APYPVCTLRH IPSSMEHSVQ 600
WAQDQFEGLF RLSTETINCY QQTCTSLSAT DRTETLALLQ QVMGVLRTRP QTWQDCVVWA 660
LGHWQLCFHD KVLEGGTQFS SGSNKCPHPL QFDPNHDMHF LYVLAAANLY ARMHGLPGSQ 720
SQPALRELLT RLLESDSRPQ NLFSAEHGQE QLKELQETLD DWRKGPPLKP VLFVKDDDSN 780
FHVDFVVAAT DLRCQNYGIL PVNHARIKQI VGRIIPAIAT STAVVAGLLG LELYKVVSGL 840
RSHGTFRHSY LHLAENHFIR SAPSAPAVQS FRDLKWTCWD RLKVPAVQPE RTLKSLLAHL 900
QEEHGLKVEM LLHHQALLYS SGWSSEKQAQ HLCLRVTELV QHVTGWKPKP GLKVLVFELS 960
CEGEEEEMAF PPLHYEL 977 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0019782; F:ISG15 activating enzyme activity; IDA:MGI.
 GO:0032020; P:ISG15-protein conjugation; IDA:MGI.
 GO:0019941; P:modification-dependent protein catabolic process; IDA:MGI. 
Interpro
 IPR009036; Molybdenum_cofac_synth_MoeB.
 IPR016040; NAD(P)-bd_dom.
 IPR000594; ThiF_NAD_FAD-bd.
 IPR018965; Ub-activating_enz_e1_C.
 IPR023280; Ub-like_act_enz_cat_cys_dom.
 IPR000127; UBact_repeat.
 IPR019572; Ubiquitin-activating_enzyme.
 IPR018075; UBQ-activ_enz_E1.
 IPR000011; UBQ/SUMO-activ_enz_E1-like. 
Pfam
 PF00899; ThiF
 PF09358; UBA_e1_C
 PF10585; UBA_e1_thiolCys
 PF02134; UBACT 
SMART
 SM00985; UBA_e1_C 
PROSITE
  
PRINTS
 PR01849; UBIQUITINACT.