CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021820
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 39S ribosomal protein L39, mitochondrial 
Protein Synonyms/Alias
 L39mt; MRP-L39 
Gene Name
 Mrpl39 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
65RTEKIEVKHVGKTDPacetylation[1]
133TFKDPDPKEVNKAYWacetylation[1]
137PDPKEVNKAYWRSCAacetylation[1]
156CVIERAFKDDYVVSLacetylation[1, 2, 3]
201ENLRSFTKDAHALIYacetylation[1, 3]
231LEIFQHNKYKVDFIEacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
 MOD_RES 123 123 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 336 AA 
Protein Sequence
MATAVGRLVL RRPGAGGGAR WRFIATSPAA ELSPTELTEM RNDLFNREKS RQLSLTPRTE 60
KIEVKHVGKT DPGTVFVMNK NISTPYSCAM HLSEWYCSKS ILALVDGQPW DMYKPLTKSC 120
EIKFLTFKDP DPKEVNKAYW RSCAMMLGCV IERAFKDDYV VSLVRAPEVP VIAGAFCYDV 180
TLDKRLDEWM PTKENLRSFT KDAHALIYRD LPFETLDVDA RVALEIFQHN KYKVDFIEEK 240
ASQNPERIVK LHRIGDFIDV SEGPLIPRTS VCFQYEVSAV HNLNPSQPNL IRRFQGLSLP 300
THLRAQFTIW DKLVERSRKM VTEDEVRQTE NTESTQ 336 
Gene Ontology
 GO:0005762; C:mitochondrial large ribosomal subunit; ISA:MGI.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; ISA:MGI.
 GO:0000002; P:mitochondrial genome maintenance; TAS:MGI.
 GO:0006412; P:translation; ISA:MGI. 
Interpro
 IPR012675; Beta-grasp_dom.
 IPR015552; Ribosomal_L39_mit.
 IPR018163; Thr/Ala-tRNA-synth_IIc_edit. 
Pfam
  
SMART
  
PROSITE
  
PRINTS