UniProt Accession

 ELP5_MOUSE; Q99L85; O08973; Q9CUX2 

Genbank Protein ID

 AF004107; AK152582; AK013662; AL596185; BC003752 

Genbank Nucleotide ID

 AAC16252.1; BAE31332.1; BAB28944.1; CAI35160.1; AAH03752.1 

Protein Name

 Elongator complex protein 5 

Protein Synonyms/Alias

 Dermal papilla-derived protein 6 homolog; Retinoic acid-induced protein 12 

Gene Name

 Elp5 

Gene Synonyms/Alias

 Derp6; Rai12 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
263	PFQFSSEKQKALLHP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May be involved in TP53-mediated transcriptional regulation. Involved in cell migration. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0033588; C:Elongator holoenzyme complex; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR019519; Histone_acetylation_protein_2. 

Pfam

 PF10483; Hap2_elong 

SMART

  

PROSITE

  

PRINTS