CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031955
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box/WD repeat-containing protein 7 
Protein Synonyms/Alias
 cDNA FLJ55681, highly similar to F-box/WD repeat protein 7 
Gene Name
 FBXW7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
236VWSAVTGKCLRTLVGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 531 AA 
Protein Sequence
MLFFKCISLL LIWLIPGQST TGLVPCSATP TTFGDLRAAN GQGQQRRRIT SVQPPTGLQE 60
WLKMFQSWSG PEKLLALDEL IDSCEPTQVK HMMQVIEPQF QRDFISLLPK ELALYVLSFL 120
EPKDLLQAAQ TCRYWRILAE DNLLWREKCK EEGIDEPLHI KRRKVIKPGF IHSPWKSAYI 180
RQHRIDTNWR RGELKSPKVL KGHDDHVITC LQFCGNRIVS GSDDNTLKVW SAVTGKCLRT 240
LVGHTGGVWS SQMRDNIIIS GSTDRTLKVW NAETGECIHT LYGHTSTVRC MHLHEKRVVS 300
GSRDATLRVW DIETGQCLHV LMGHVAAVRC VQYDGRRVVS GAYDFMVKVW DPETETCLHT 360
LQGHTNRVYS LQFDGIHVVS GSLDTSIRVW DVETGNCIHT LTGHQSLTSG MELKDNILVS 420
GNADSTVKIW DIKTGQCLQT LQGPNKHQSA VTCLQFNKNF VITSSDDGTV KLWDLKTGEF 480
IRNLVTLESG GSGGVVWRIR ASNTKLVCAV GSRNGTEETK LLVLDFDVDM K 531 
Gene Ontology
  
Interpro
 IPR001810; F-box_dom_cyclin-like.
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00256; FBOX
 SM00320; WD40 
PROSITE
 PS50181; FBOX
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.