UniProt Accession

 B4DV54_HUMAN; B4DV54 

Genbank Protein ID

 AC074032; AC139016; AK300937; CH471111 

Genbank Nucleotide ID

 BAG62566.1; EAW58133.1 

Protein Name

 Ceramide synthase 5 

Protein Synonyms/Alias

 LAG1 longevity assurance homolog 5 (S. cerevisiae), isoform CRA_c; cDNA FLJ59438, highly similar to LAG1 longevity assurance homolog 5 

Gene Name

 LASS5 

Gene Synonyms/Alias

 CERS5; hCG_1774451 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	KRLEGLSKQLDWNVR	ubiquitination	[1]
63	QLDWNVRKIQCWFRH	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; DNA-binding; Homeobox; Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 334 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. 

Interpro

 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR016439; Longevity_assurance_LAG1_LAC1.
 IPR006634; TLC-dom. 

Pfam

 PF00046; Homeobox
 PF03798; TRAM_LAG1_CLN8 

SMART

 SM00389; HOX
 SM00724; TLC 

PROSITE

 PS50071; HOMEOBOX_2
 PS50922; TLC 

PRINTS