CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Thioredoxin reductase 2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 TXNRD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
114EAVQNHVKSLNWGHRacetylation[1]
130QLQDRKVKYFNIKASacetylation[1]
306TRSLNLEKAGVDTSPubiquitination[2]
317DTSPDTQKILVDSREubiquitination[2]
483TCSEEVVKLRISKRSacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Redox-active center; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 501 AA 
Protein Sequence
MAAMAVALRG LGGRFRWRTQ AVAGGVRGAA RGAAAAQLGR KVAVVDYVEP SPQGTRWGLG 60
GTCVNVGCIP KKLMHQAALL GGLIQDAPNY GWEVAQPVPH DWRKMAEAVQ NHVKSLNWGH 120
RVQLQDRKVK YFNIKASFVD EHTVCGVAKG GKEILLSADH IIIATGGRPR YPTHIEGALE 180
YGITSDDIFW LKESPGKTLV VGASYVALEC AGFLTGIGLD TTIMMRSIPL RGFDQQMSSM 240
VIEHMASHGT RFLRGCAPSR VRRLPDGQLQ VTWEDSTTGK EDTGTFDTVL WAIGRVPDTR 300
SLNLEKAGVD TSPDTQKILV DSREATSVPH IYAIGDVVEG RPELTPIAIM AGRLLVQRLF 360
GGSSDLMDYD NVPTTVFTPL EYGCVGLSEE EAVARHGQEH VEVYHAHYKP LEFTVAGRDA 420
SQCYVKMVCL REPPQLVLGL HFLGPNAGEV TQGFALGIKC GASYAQVMRT VGIHPTCSEE 480
VVKLRISKRS GLDPTVTGCC G 501 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0004791; F:thioredoxin-disulfide reductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 
Interpro
 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom.
 IPR006338; Thioredoxin/glutathione_Rdtase. 
Pfam
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 
SMART
  
PROSITE
 PS00076; PYRIDINE_REDOX_1 
PRINTS
 PR00368; FADPNR.