CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025361
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphorylase 
Protein Synonyms/Alias
  
Gene Name
 Pygl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
79EYGIFNQKIREGWQVubiquitination[1]
204EGKELRLKQEYFVVAubiquitination[1]
229KASKFGSKDGMGTVFubiquitination[1]
268RIFVDIEKLPWAKAWacetylation[2]
268RIFVDIEKLPWAKAWubiquitination[1]
273IEKLPWAKAWEITKKacetylation[3]
273IEKLPWAKAWEITKKsuccinylation[3]
273IEKLPWAKAWEITKKubiquitination[1]
279AKAWEITKKTFAYTNubiquitination[1]
280KAWEITKKTFAYTNHubiquitination[1]
304WPVELVEKLLPRHLEubiquitination[1]
319IIYEINQKHLDRIVAacetylation[4]
319IIYEINQKHLDRIVAubiquitination[1]
330RIVALFPKDISRMRRubiquitination[1]
347LIEEEGGKRINMAHLubiquitination[1]
374KIHSDIVKTQVFKDFubiquitination[1]
379IVKTQVFKDFSELEPubiquitination[1]
388FSELEPDKFQNKTNGubiquitination[1]
392EPDKFQNKTNGITPRubiquitination[1]
423KIGEDYVKDLSQLTKubiquitination[1]
430KDLSQLTKLHSFVSDubiquitination[1]
454VKQENKLKFSQFLEKubiquitination[1]
461KFSQFLEKEYKVKINubiquitination[1]
466LEKEYKVKINPSSMFubiquitination[1]
518RTVIIGGKAAPGYHMubiquitination[1]
549NDPMVGSKLKVIFLEacetylation[2]
549NDPMVGSKLKVIFLEubiquitination[1]
551PMVGSKLKVIFLENYubiquitination[1]
565YRVSLAEKVIPATDLubiquitination[1]
633DDVAALDKKGYEAKEacetylation[2, 4]
633DDVAALDKKGYEAKEubiquitination[1]
639DKKGYEAKEYYEALPacetylation[2]
639DKKGYEAKEYYEALPubiquitination[1]
682LFYHDRFKVFADYEAubiquitination[1]
705SQLYMNQKAWNTMVLubiquitination[1]
713AWNTMVLKNIAASGKacetylation[2]
713AWNTMVLKNIAASGKubiquitination[1]
720KNIAASGKFSSDRTIubiquitination[1]
732RTIKEYAKDIWNMEPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599] 
Functional Description
 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). 
Sequence Annotation
  
Keyword
 Carbohydrate metabolism; Complete proteome; Glycosyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 759 AA 
Protein Sequence
MGRTLQNTMI NLGLQNACDE AIYQLGLDME ELEEIEEDAG LGNGGLGRLA ACFLDSMATL 60
GLAAYGYGIR YEYGIFNQKI REGWQVEEAD DWLRHGNPWE KARPEFMLPV HFYGRVEHTQ 120
TGTKWVDTQV VLALPYDTPV PGYMNNTVNT MRLWSARAPN DFNLQDFNVG DYIQAVLDRN 180
LAENISRVLY PNDNFFEGKE LRLKQEYFVV AATLQDVIRR FKASKFGSKD GMGTVFDAFP 240
DQVAIQLNDT HPALAIPELM RIFVDIEKLP WAKAWEITKK TFAYTNHTVL PEALERWPVE 300
LVEKLLPRHL EIIYEINQKH LDRIVALFPK DISRMRRMSL IEEEGGKRIN MAHLCIVGCH 360
AVNGVAKIHS DIVKTQVFKD FSELEPDKFQ NKTNGITPRR WLLLCNPGLA DLIAEKIGED 420
YVKDLSQLTK LHSFVSDDIF LREIAKVKQE NKLKFSQFLE KEYKVKINPS SMFDVHVKRI 480
HEYKRQLLNC LHVITMYNRI KKDPKKFFVP RTVIIGGKAA PGYHMAKMII KLITSVAEVV 540
NNDPMVGSKL KVIFLENYRV SLAEKVIPAT DLSEQISTAG TEASGTGNMK FMLNGALTIG 600
TMDGANVEMA EEAGEENLFI FGMRVDDVAA LDKKGYEAKE YYEALPELKL VIDQIDNGFF 660
SPNQPDLFKD IINMLFYHDR FKVFADYEAY VKCQEKVSQL YMNQKAWNTM VLKNIAASGK 720
FSSDRTIKEY AKDIWNMEPS DLKISLSNES SNGVSANGK 759 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0016208; F:AMP binding; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0032052; F:bile acid binding; IEA:Compara.
 GO:0030246; F:carbohydrate binding; IEA:Compara.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0008184; F:glycogen phosphorylase activity; IDA:MGI.
 GO:0002060; F:purine nucleobase binding; IEA:Compara.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0019842; F:vitamin binding; IEA:Compara.
 GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0005980; P:glycogen catabolic process; IEA:Compara.
 GO:0005977; P:glycogen metabolic process; IDA:MGI. 
Interpro
 IPR011833; Glycg_phsphrylas.
 IPR000811; Glyco_trans_35. 
Pfam
 PF00343; Phosphorylase 
SMART
  
PROSITE
 PS00102; PHOSPHORYLASE 
PRINTS