| Tag | Content |
|---|
| CPLM ID | CPLM-006508 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Replication factor C subunit 1 |
Protein Synonyms/Alias | Activator 1 140 kDa subunit; Activator 1 subunit 1; Germline transcription factor 1; Replication factor C large subunit |
Gene Name | Gnf1 |
Gene Synonyms/Alias | CG1119 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 10 | RGIDSFFKRLPAKAK | acetylation | [1] | | 17 | KRLPAKAKSAEAENG | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds to the primer-template junction (By similarity). |
Sequence Annotation | DOMAIN 232 322 BRCT.
NP_BIND 487 494 ATP (By similarity).
MOTIF 955 959 Nuclear localization signal (Potential).
MOD_RES 18 18 Phosphoserine.
MOD_RES 28 28 Phosphoserine.
MOD_RES 40 40 Phosphoserine.
MOD_RES 41 41 Phosphoserine.
MOD_RES 48 48 Phosphoserine.
MOD_RES 58 58 Phosphoserine.
MOD_RES 60 60 Phosphothreonine.
MOD_RES 62 62 Phosphoserine.
MOD_RES 63 63 Phosphoserine.
MOD_RES 71 71 Phosphothreonine.
MOD_RES 128 128 Phosphoserine.
MOD_RES 137 137 Phosphoserine.
MOD_RES 149 149 Phosphoserine.
MOD_RES 154 154 Phosphoserine.
MOD_RES 156 156 Phosphoserine.
MOD_RES 164 164 Phosphoserine.
MOD_RES 194 194 Phosphoserine.
MOD_RES 197 197 Phosphothreonine.
MOD_RES 938 938 Phosphoserine.
MOD_RES 939 939 Phosphoserine. |
Keyword | Activator; ATP-binding; Complete proteome; DNA replication; DNA-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 986 AA |
Protein Sequence | MQRGIDSFFK RLPAKAKSAE AENGETPSKA PKRRKAVIIS SDEDEVVSPP ETKKRKASKT 60
ASSEDDVVAA TPEPIAKKAR NGQKPALSKL KRHVDPTELF GGETKRVIVP KPKTKAVLEF 120
ENEDIDRSLM EVDLDESIKE AAPEKKVHSI TRSSPSPKRA KNSSPEPPKP KSTKSKATTP 180
RVKKEKPAAD LESSVLTDEE RHERKRASAV LYQKYKNRSS CLNPGSKEIP KGSPDCLSGL 240
TFVVTGVLES MEREEAESVI KEYGGKVMTV VGKKLKYLVV GEEAGPKKLA VAEELNIPIL 300
SEDGLFDLIR EKSGIAKQVK EEKKSPKKEH SSEEKGKKEV KTSRRSSDKK EKEATKLKYG 360
EKHDIAKHKV KEEHTSPKET KDKLNDVPAV TLKVKKEPSS QKEHPPSPRT ADLKTLDVVG 420
MAWVDKHKPT SIKEIVGQAG AASNVTKLMN WLSKWYVNHD GNKKPQRPNP WAKNDDGSFY 480
KAALLSGPPG IGKTTTATLV VKELGFDAVE FNASDTRSKR LLKDEVSTLL SNKSLSGYFT 540
GQGQAVSRKH VLIMDEVDGM AGNEDRGGMQ ELIALIKDSS IPIICMCNDR NHPKIRSLVN 600
YCYDLRFQRP RLEQIKGKIM SICFKEKVKI SPAKVEEIIA ATNNDIRQSI NHIALLSAKE 660
DASQKSGQQV ATKDLKLGPW EVVRKVFTAD EHKHMSFADK SDLFFHDYSL APLFVQQNYL 720
QVLPQGNKKD VLAKVAATAD ALSLGDLVEK RIRANSAWSL LPTQAFFSSV LPGEHMCGHF 780
TGQINFPGWL GKNSKSGKRA RLAQELHDHT RVCTSGSRLS VRLDYAPFLL DNIVRPLAKD 840
GQEGVPAALD VMKDYHLLRE DLDSLVELTS WPGKKSPLDA VDGRVKAALT RSYNKEVMAY 900
SYSAQAGIKK KKSEAAGADD DYLDEGPGEE DGAGGHLSSE EDEDKDNLEL DSLIKAKKRT 960
TTSKASGGSK KATSSTASKS KAKAKK 986 |
Gene Ontology | GO:0005663; C:DNA replication factor C complex; NAS:FlyBase. GO:0005875; C:microtubule associated complex; IDA:FlyBase. GO:0005634; C:nucleus; IDA:FlyBase. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003677; F:DNA binding; IDA:FlyBase. GO:0003689; F:DNA clamp loader activity; IEA:InterPro. GO:0006260; P:DNA replication; NAS:FlyBase. GO:0046331; P:lateral inhibition; IMP:FlyBase. GO:0022008; P:neurogenesis; IMP:FlyBase. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |