| Tag | Content |
|---|
| CPLM ID | CPLM-026139 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 2-isopropylmalate synthase |
Protein Synonyms/Alias | Alpha-IPM synthase; Alpha-isopropylmalate synthase |
Gene Name | leuA |
Gene Synonyms/Alias | TTHA1210 |
Created Date | July 27, 2013 |
Organism | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
NCBI Taxa ID | 300852 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 115 | HLQYMLRKTEEEVLE | acetylation | [1] |
|
Reference | [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus. Okanishi H, Kim K, Masui R, Kuramitsu S. J Proteome Res. 2013 Aug 1;. [ PMID: 23901841] |
Functional Description | Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity). |
Sequence Annotation | |
Keyword | Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Leucine biosynthesis; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 520 AA |
Protein Sequence | MEKERHIRIF DTTLRDGEQS PGVALSLDQK LEIAQALAQL NVDIIEAGFP VSGPMEFEAV 60
RRIATEVKGP IIAALARTHT LDIDQAAKAL EKAEKPRIHV FTSASKVHLQ YMLRKTEEEV 120
LEMADRMVRY ARRYVDDVEF SAQDVMRADW EFVKRLYEVA IEAGATTINI PDTTGYGTPQ 180
EYGALIRRIR DEVVRGRDVV ISTHTHDDLG MATANALAGV ENGAGQIECT INGIGERAGN 240
CALEEVVMAL YVRRDWYKAY TRINTREIYR VSRLVERYTG MPVPPNKAIV GDNAFAHESG 300
IHQDGVIKHR ATYEIMDAEL IGRRPAVLVL GKHSGRAAFK KALEDLGYKD LSEEEVKKLF 360
ARFKEIAEKK GPLSAEELQA LVESEREPTS HFFQLEHVQF FSGSGLLPTA TVKVKTPDGE 420
RLATHTGDGP VDAVYKAIQE AIGLRPELEL YRVEAITGST EALGQVTVRL RLGELQAVGV 480
GVSPDIIEAS ALAFLDAAGK LASGRATRHP PSIEEVHRGV 520 |
Gene Ontology | GO:0003852; F:2-isopropylmalate synthase activity; IEA:HAMAP. GO:0009098; P:leucine biosynthetic process; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |