| Tag | Content |
|---|
| CPLM ID | CPLM-018239 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone-lysine N-methyltransferase SETD7 |
Protein Synonyms/Alias | Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9 |
Gene Name | SETD7 |
Gene Synonyms/Alias | KIAA1717; KMT7; SET7; SET9 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 158 | ERTALYGKFIDGEMI | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. |
Sequence Annotation | REPEAT 36 58 MORN 1.
REPEAT 59 81 MORN 2.
REPEAT 106 128 MORN 3.
DOMAIN 214 336 SET.
REGION 226 228 S-adenosyl-L-methionine binding.
REGION 256 258 Substrate binding.
REGION 266 268 Substrate binding.
REGION 296 297 S-adenosyl-L-methionine binding.
BINDING 245 245 Substrate.
BINDING 317 317 Substrate.
BINDING 335 335 Substrate; via carbonyl oxygen.
BINDING 356 356 S-adenosyl-L-methionine; via carbonyl |
Keyword | 3D-structure; Activator; Chromatin regulator; Chromosome; Complete proteome; Direct protein sequencing; Methyltransferase; Nucleus; Reference proteome; Repeat; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 366 AA |
Protein Sequence | MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE 60
GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW 120
IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP 180
HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT 240
VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT 300
PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF 360
QATQQK 366 |
Gene Ontology | GO:0005694; C:chromosome; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0018024; F:histone-lysine N-methyltransferase activity; IDA:UniProtKB. GO:0018027; P:peptidyl-lysine dimethylation; IDA:UniProtKB. GO:0018026; P:peptidyl-lysine monomethylation; IDA:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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