CPLM-000669

Genbank Nucleotide ID

Zinc finger HIT domain-containing protein 1

Protein Synonyms/Alias

Cyclin-G1-binding protein 1; Zinc finger protein subfamily 4A member 1; p18 Hamlet

Homo sapiens (Human)

Position	Peptide	Type	References
53	AGLPQLGKRLPQFDD	ubiquitination	[1, 2]
66	DDDADTGKKKKKTRG	acetylation	[3]
67	DDADTGKKKKKTRGD	ubiquitination	[2]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]

Functional Description

Seems to play a role in p53-mediated apoptosis induction.

ZN_FING 117 149 HIT-type.
MOD_RES 103 103 Phosphothreonine; by MAPK11 and MAPK14.

Coiled coil; Complete proteome; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.