CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028715
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Adenosylhomocysteinase 
Protein Synonyms/Alias
  
Gene Name
 Ahcy 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
4****MSDKLPYKVADacetylation[1]
8MSDKLPYKVADIGLAacetylation[2]
8MSDKLPYKVADIGLAsuccinylation[2]
8MSDKLPYKVADIGLAubiquitination[3]
20GLAAWGRKALDIAENubiquitination[3]
43REMYSASKPLKGARIacetylation[4]
43REMYSASKPLKGARIubiquitination[3]
46YSASKPLKGARIAGCubiquitination[3]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 95 AA 
Protein Sequence
MSDKLPYKVA DIGLAAWGRK ALDIAENEMP GLMRMREMYS ASKPLKGARI AGCLHMTVET 60
AVLIETLVAL GAEDHAAAAI AKAGIPVFAW KGETD 95 
Gene Ontology
 GO:0004013; F:adenosylhomocysteinase activity; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro. 
Interpro
 IPR000043; Adenosylhomocysteinase. 
Pfam
 PF05221; AdoHcyase 
SMART
  
PROSITE
  
PRINTS