UniProt Accession

 DEDD2_HUMAN; Q8WXF8; Q8NBR2; Q8NES1; Q8TAA8; Q96D35 

Genbank Protein ID

 AF443591; AF457575; AY125488; AK075328; BC013372; BC027930 

Genbank Nucleotide ID

 AAL48220.1; AAM10835.1; AAM95240.1; BAC11551.1; AAH13372.2; AAH27930.1 

Protein Name

 DNA-binding death effector domain-containing protein 2 

Protein Synonyms/Alias

 DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3 

Gene Name

 DEDD2 

Gene Synonyms/Alias

 FLAME3; PSEC0004 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
155	ETGSPPTKRQRRSRG	ubiquitination	[1]
193	ARPSSEGKVTCDIRL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. 

Sequence Annotation

 DOMAIN 25 104 DED.
 MOTIF 104 109 Nuclear localization signal (Potential).
 MOTIF 155 173 Bipartite nuclear localization signal  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 326 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0030159; F:receptor signaling complex scaffold activity; NAS:UniProtKB.
 GO:0030262; P:apoptotic nuclear changes; IDA:UniProtKB.
 GO:0019725; P:cellular homeostasis; NAS:UniProtKB.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IMP:UniProtKB.
 GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:0006396; P:RNA processing; NAS:UniProtKB.
 GO:0016075; P:rRNA catabolic process; NAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR001875; DED. 

Pfam

 PF01335; DED 

SMART

 SM00031; DED 

PROSITE

 PS50168; DED 

PRINTS