CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016008
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myotubularin-related protein 12 
Protein Synonyms/Alias
  
Gene Name
 Mtmr12 
Gene Synonyms/Alias
 Kiaa1682 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
135PLFGQLKKYPEKLVIubiquitination[1]
139QLKKYPEKLVIHCKDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location (By similarity). 
Sequence Annotation
 DOMAIN 205 643 Myotubularin phosphatase.
 REGION 449 558 Interaction with MTM1 (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 747 AA 
Protein Sequence
MLGKGGVGGG GGTKAPKPSF VSYVRPEEIH TDEKEVTEKE VTLHLLPGEQ LLCEASTVLK 60
YVQEDSCQRG VYGRLVCTDF KISFLGDEDS ALDNGGEAQF KNKIIGVNDV PLHCVDQIYG 120
VFDEKKKPLF GQLKKYPEKL VIHCKDLRVL HFCLRYTKEE EVKRIVSGII HHTQSPKLLK 180
RLFLFSYAAA VHGTATDSRN CTVMFDTPKD WCWELERTKG SVKYRTVSVN EGYRVSDRLP 240
AYFVVPTPLP EDDVRRFQGH GIPIWCWSCH NGSALLKMSA LPKEQDDGAL QVQKSFLDGI 300
YKTIHRPPYE MVKTEDLSSN FLSLQEIQSA YCKFKQLFLI DNSSEFWDTD IKWFSLLESS 360
SWLDIIRRCL KKAIEITECL EAQNVNVLLL EENASDLCCL LSSLVQVMMD AHCRTRTGFQ 420
SLIQKEWVMG GHSFLDRCNH LHQSDKEEVP IFLLFLDCVW QLVHQYPPAF EFTETYLTVL 480
SDSLYIPIFS TFFFNSPHQK DTNMGRENLD AQSKPLTLLT VWDWSVQFEP KAQTLLRNPL 540
YVEKPKLDRG QQKGSRFKHQ RQLSLPLTQS KSSPKRGFFR EETDHLIKNL LGKRISKLIN 600
SSDDLQDSSR EFYDSWHSKP TDYHGLLLPH IEGPEIKVWA QRYLRWIPEA QILGGGRVAT 660
MGKLLEMMEE VQSLQEKIEA RHHRQEAVHA EAPGLLRNSV RLSSLFPFAL LQRHSAKPVL 720
PTSGWKALGG EDDLAKREDE FVDLGDV 747 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016791; F:phosphatase activity; IEA:InterPro. 
Interpro
 IPR022587; Myotubularin_assoc.
 IPR017906; Myotubularin_phosphatase_dom.
 IPR011993; PH_like_dom. 
Pfam
 PF12578; 3-PAP 
SMART
  
PROSITE
 PS51339; PPASE_MYOTUBULARIN
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2 
PRINTS