CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022189
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exocyst complex component 1 
Protein Synonyms/Alias
 Exocyst complex component Sec3 
Gene Name
 EXOC1 
Gene Synonyms/Alias
 SEC3; SEC3L1; BM-012 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5***MTAIKHALQRDIacetylation[1]
288DLAKGHIKALQEGDLubiquitination[2, 3]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. 
Sequence Annotation
 MOD_RES 471 471 Phosphothreonine.
 MOD_RES 473 473 Phosphoserine.
 MOD_RES 487 487 Phosphoserine.
 MOD_RES 501 501 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Exocytosis; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 894 AA 
Protein Sequence
MTAIKHALQR DIFTPNDERL LSIVNVCKAG KKKKNCFLCA TVTTERPVQV KVVKVKKSDK 60
GDFYKRQIAW ALRDLAVVDA KDAIKENPEF DLHFEKIYKW VASSTAEKNA FISCIWKLNQ 120
RYLRKKIDFV NVSSQLLEES VPSGENQSVT GGDEEVVDEY QELNAREEQD IEIMMEGCEY 180
AISNAEAFAE KLSRELQVLD GANIQSIMAS EKQVNILMKL LDEALKEVDQ IELKLSSYEE 240
MLQSVKEQMD QISESNHLIH LSNTNNVKLL SEIEFLVNHM DLAKGHIKAL QEGDLASSRG 300
IEACTNAADA LLQCMNVALR PGHDLLLAVK QQQQRFSDLR ELFARRLASH LNNVFVQQGH 360
DQSSTLAQHS VELTLPNHHP FHRDLLRYAK LMEWLKSTDY GKYEGLTKNY MDYLSRLYER 420
EIKDFFEVAK IKMTGTTKES KKFATLPRKE SAVKQETESL HGSSGKLTGS TSSLNKLSVQ 480
SSGNRRSQSS SLLDMGNMSA SDLDVADRTK FDKIFEQVLS ELEPLCLAEQ DFISKFFKLQ 540
QHQSMPGTMA EAEDLDGGTL SRQHNCGTPL PVSSEKDMIR QMMIKIFRCI EPELNNLIAL 600
GDKIDSFNSL YMLVKMSHHV WTAQNVDPAS FLSTTLGNVL VTVKRNFDKC ISNQIRQMEE 660
VKISKKSKVG ILPFVAEFEE FAGLAESIFK NAERRGDLDK AYTKLIRGVF VNVEKVANES 720
QKTPRDVVMM ENFHHIFATL SRLKISCLEA EKKEAKQKYT DHLQSYVIYS LGQPLEKLNH 780
FFEGVEARVA QGIREEEVSY QLAFNKQELR KVIKEYPGKE VKKGLDNLYK KVDKHLCEEE 840
NLLQVVWHSM QDEFIRQYKH FEGLIARCYP GSGVTMEFTI QDILDYCSSI AQSH 894 
Gene Ontology
 GO:0000145; C:exocyst; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006887; P:exocytosis; NAS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR019160; Exocyst_Exoc1. 
Pfam
 PF09763; Sec3 
SMART
  
PROSITE
  
PRINTS