UniProt Accession

 VP37A_HUMAN; Q8NEZ2; Q336D5; Q6NW27; Q8N3D7; Q8TBL7; Q96DL9 

Genbank Protein ID

 AY033079; AF547097; AK057204; AL834189; BC022363; BC067754 

Genbank Nucleotide ID

 AAK54349.1; AAQ12067.1; BAB71381.1; CAD38883.1; AAH22363.1; AAH67754.1 

Protein Name

 Vacuolar protein sorting-associated protein 37A 

Protein Synonyms/Alias

 hVps37A; ESCRT-I complex subunit VPS37A; Hepatocellular carcinoma-related protein 1 

Gene Name

 VPS37A 

Gene Synonyms/Alias

 HCRP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	LTSLQQQKQRLIESL	ubiquitination	[1, 2]
335	SALQARLKVAAHEAE	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. 

Sequence Annotation

 DOMAIN 308 397 VPS37 C-terminal.
 MOD_RES 18 18 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; Endosome; Hereditary spastic paraplegia; Membrane; Neurodegeneration; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 397 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:HPA.
 GO:0000813; C:ESCRT I complex; IDA:UniProtKB.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0046788; P:egress of virus within host cell; TAS:Reactome.
 GO:0016197; P:endosomal transport; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:UniProtKB.
 GO:0019082; P:viral protein processing; TAS:Reactome.
 GO:0019068; P:virion assembly; TAS:Reactome. 

Interpro

 IPR009851; Mod_r.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF07200; Mod_r 

SMART

  

PROSITE

 PS51314; VPS37_C 

PRINTS