UniProt Accession

 SNRPA_MOUSE; Q62189; Q52LA2 

Genbank Protein ID

 L15447; BC003229; BC094006; BC096648 

Genbank Nucleotide ID

 AAC37611.1; AAH03229.1; AAH94006.1; AAH96648.1 

Protein Name

 U1 small nuclear ribonucleoprotein A 

Protein Synonyms/Alias

 U1 snRNP A; U1-A; U1A 

Gene Name

 Snrpa 

Gene Synonyms/Alias

 Rnu1a-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
26	YINNLNEKIKKDELK	ubiquitination	[1]
94	PMRIQYAKTDSDIIA	ubiquitination	[1]
102	TDSDIIAKMKGTYVE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro (By similarity). 

Sequence Annotation

 DOMAIN 16 95 RRM 1.
 DOMAIN 213 287 RRM 2.
 MOD_RES 66 66 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 287 AA 

Protein Sequence

Gene Ontology

 GO:0005681; C:spliceosomal complex; ISS:HGNC.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0017069; F:snRNA binding; IEA:InterPro.
 GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR024888; U1_snRNP_A/U2_snRNP_B''. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS