CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013962
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FK506-binding protein 15 
Protein Synonyms/Alias
 FKBP-15; 133 kDa FK506-binding protein; 133 kDa FKBP; FKBP-133; WASP and FKBP-like; WAFL 
Gene Name
 FKBP15 
Gene Synonyms/Alias
 KIAA0674 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92YTNGQYVKQGKFGAAacetylation[1]
774SYQEELDKLRQLLKKubiquitination[2, 3]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement. 
Sequence Annotation
 DOMAIN 197 290 PPIase FKBP-type.
 REGION 72 169 Important for function in growth cone
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 92 92 N6-acetyllysine.
 MOD_RES 307 307 Phosphoserine (By similarity).
 MOD_RES 326 326 Phosphoserine.
 MOD_RES 346 346 Phosphoserine.
 MOD_RES 356 356 Phosphoserine.
 MOD_RES 939 939 Phosphoserine.
 MOD_RES 940 940 Phosphoserine.
 MOD_RES 941 941 Phosphoserine.
 MOD_RES 956 956 Phosphoserine.
 MOD_RES 979 979 Phosphoserine.
 MOD_RES 1097 1097 Phosphoserine (By similarity).
 MOD_RES 1099 1099 Phosphothreonine (By similarity).
 MOD_RES 1114 1114 Phosphoserine.
 MOD_RES 1161 1161 Phosphoserine.
 MOD_RES 1162 1162 Phosphoserine.
 MOD_RES 1164 1164 Phosphoserine.
 MOD_RES 1195 1195 Phosphoserine.
 MOD_RES 1203 1203 Phosphothreonine.  
Keyword
 Acetylation; Actin-binding; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Endocytosis; Endosome; Phosphoprotein; Polymorphism; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1219 AA 
Protein Sequence
MFGAGDEDDT DFLSPSGGAR LASLFGLDQA AAGHGNEFFQ YTAPKQPKKG QGTAATGNQA 60
TPKTAPATMS TPTILVATAV HAYRYTNGQY VKQGKFGAAV LGNHTAREYR ILLYISQQQP 120
VTVARIHVNF ELMVRPNNYS TFYDDQRQNW SIMFESEKAA VEFNKQVCIA KCNSTSSLDA 180
VLSQDLIVAD GPAVEVGDSL EVAYTGWLFQ NHVLGQVFDS TANKDKLLRL KLGSGKVIKG 240
WEDGMLGMKK GGKRLLIVPP ACAVGSEGVI GWTQATDSIL VFEVEVRRVK FARDSGSDGH 300
SVSSRDSAAP SPIPGADNLS ADPVVSPPTS IPFKSGEPAL RTKSNSLSEQ LAINTSPDAV 360
KAKLISRMAK MGQPMLPILP PQLDSNDSEI EDVNTLQGGG QPVVTPSVQP SLHPAHPALP 420
QMTSQAPQPS VTGLQAPSAA LMQVSSLDSH SAVSGNAQSF QPYAGMQAYA YPQASAVTSQ 480
LQPVRPLYPA PLSQPPHFQG SGDMASFLMT EARQHNTEIR MAVSKVADKM DHLMTKVEEL 540
QKHSAGNSML IPSMSVTMET SMIMSNIQRI IQENERLKQE ILEKSNRIEE QNDKISELIE 600
RNQRYVEQSN LMMEKRNNSL QTATENTQAR VLHAEQEKAK VTEELAAATA QVSHLQLKMT 660
AHQKKETELQ MQLTESLKET DLLRGQLTKV QAKLSELQET SEQAQSKFKS EKQNRKQLEL 720
KVTSLEEELT DLRVEKESLE KNLSERKKKS AQERSQAEEE IDEIRKSYQE ELDKLRQLLK 780
KTRVSTDQAA AEQLSLVQAE LQTQWEAKCE HLLASAKDEH LQQYQEVCAQ RDAYQQKLVQ 840
LQEKCLALQA QITALTKQNE QHIKELEKNK SQMSGVEAAA SDPSEKVKKI MNQVFQSLRR 900
EFELEESYNG RTILGTIMNT IKMVTLQLLN QQEQEKEESS SEEEEEKAEE RPRRPSQEQS 960
ASASSGQPQA PLNRERPESP MVPSEQVVEE AVPLPPQALT TSQDGHRRKG DSEAEALSEI 1020
KDGSLPPELS CIPSHRVLGP PTSIPPEPLG PVSMDSECEE SLAASPMAAK PDNPSGKVCV 1080
REVAPDGPLQ ESSTRLSLTS DPEEGDPLAL GPESPGEPQP PQLKKDDVTS STGPHKELSS 1140
TEAGSTVAGA ALRPSHHSQR SSLSGDEEDE LFKGATLKAL RPKAQPEEED EDEVSMKGRP 1200
PPTPLFGDDD DDDDIDWLG 1219 
Gene Ontology
 GO:0005884; C:actin filament; IEA:Compara.
 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR001179; PPIase_FKBP_dom. 
Pfam
 PF00254; FKBP_C 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS