UniProt Accession

 FUND1_HUMAN; Q8IVP5 

Genbank Protein ID

 AL136137; AL022163; AL022163; AL136137; BC035015; BC042813 

Genbank Nucleotide ID

 CAI40461.1; CAI40461.1; CAI42944.1; CAI42944.1; AAH35015.1; AAH42813.1 

Protein Name

 FUN14 domain-containing protein 1 

Protein Synonyms/Alias

  

Gene Name

 FUNDC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
119	QIKKRANKAAPEINN	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. 

Sequence Annotation

 MOTIF 18 21 YXXL.
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 18 18 Phosphotyrosine; by SRC.  

Keyword

 Autophagy; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 155 AA 

Protein Sequence

Gene Ontology

 GO:0031307; C:integral to mitochondrial outer membrane; IDA:UniProtKB.
 GO:0000422; P:mitochondrion degradation; IDA:UniProtKB.
 GO:0001666; P:response to hypoxia; IDA:UniProtKB. 

Interpro

 IPR007014; FUN14. 

Pfam

 PF04930; FUN14 

SMART

  

PROSITE

  

PRINTS