UniProt Accession

 RL35A_MOUSE; O55142 

Genbank Protein ID

 Y16430; AK028214 

Genbank Nucleotide ID

 CAA76215.2; BAC25818.1 

Protein Name

 60S ribosomal protein L35a 

Protein Synonyms/Alias

  

Gene Name

 Rpl35a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
8	MSGRLWCKAIFAGYK	acetylation	[1]
15	KAIFAGYKRGLRNQR	acetylation	[1]
15	KAIFAGYKRGLRNQR	ubiquitination	[2]
29	REHTALLKIEGVYAR	acetylation	[1]
45	ETEFYLGKRCAYVYK	ubiquitination	[2]
63	NTVTPGGKPNKTRVI	acetylation	[3]
63	NTVTPGGKPNKTRVI	succinylation	[3]
73	KTRVIWGKVTRAHGN	acetylation	[1]
95	FRSNLPAKAIGHRIR	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Required for the proliferation and viability of hematopoietic cells (By similarity). Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (By similarity). 

Sequence Annotation

 MOD_RES 8 8 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; IEA:Compara.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0042273; P:ribosomal large subunit biogenesis; IEA:Compara.
 GO:0006364; P:rRNA processing; IEA:Compara.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR001780; Ribosomal_L35A.
 IPR018266; Ribosomal_L35Ae_CS.
 IPR009000; Transl_elong_init/rib_B-barrel. 

Pfam

 PF01247; Ribosomal_L35Ae 

SMART

  

PROSITE

 PS01105; RIBOSOMAL_L35AE 

PRINTS