| Tag | Content |
|---|
| CPLM ID | CPLM-000589 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dual specificity protein kinase CLK4 |
Protein Synonyms/Alias | CDC-like kinase 4 |
Gene Name | Clk4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 479 | HPFFDLLKRK***** | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
Sequence Annotation | DOMAIN 159 475 Protein kinase.
NP_BIND 165 173 ATP (By similarity).
ACT_SITE 286 286 Proton acceptor (By similarity).
BINDING 189 189 ATP (By similarity).
MOD_RES 136 136 Phosphoserine (By similarity).
MOD_RES 138 138 Phosphoserine (By similarity). |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 481 AA |
Protein Sequence | MRHSKRTHCP DWDSRESWGH ESYSGSHKRK RRSHSSTQEN RHCKPHHQFK DSDCHYLEAR 60
CLNERDYRDR RYIDEYRNDY CEGYVPRHYH RDVESTYRIH CSKSSVRSRR SSPKRKRNRP 120
CASHQSHSKS HRRKRSRSIE DDEEGHLICQ SGDVLRARYE IVDTLGEGAF GKVVECIDHG 180
MDGLHVAVKI VKNVGRYREA ARSEIQVLEH LNSTDPNSVF RCVQMLEWFD HHGHVCIVFE 240
LLGLSTYDFI KENSFLPFQI DHIRQMAYQI CQSINFLHHN KLTHTDLKPE NILFVKSDYV 300
VKYNSKMKRD ERTLKNTDIK VVDFGSATYD DEHHSTLVST RHYRAPEVIL ALGWSQPCDV 360
WSIGCILIEY YLGFTVFQTH DSKEHLAMME RILGPIPAHM IQKTRKRKYF HHNQLDWDEH 420
SSAGRYVRRR CKPLKEFMLC HDEEHEKLFD LVRRMLEYDP ARRITLDEAL QHPFFDLLKR 480
K 481 |
Gene Ontology | GO:0005634; C:nucleus; IDA:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC. GO:0004713; F:protein tyrosine kinase activity; IDA:MGI. GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI. GO:0046777; P:protein autophosphorylation; IDA:MGI. GO:0043484; P:regulation of RNA splicing; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |