UniProt Accession

 SOX2_MOUSE; P48432 

Genbank Protein ID

 U31967; X94127 

Genbank Nucleotide ID

 AAC31791.1; CAA63847.1 

Protein Name

 Transcription factor SOX-2 

Protein Synonyms/Alias

  

Gene Name

 Sox2 

Gene Synonyms/Alias

 Sox-2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
37	AATGGNQKNSPDRVK	acetylation	[1]
60	WSRGQRRKMAQENPK	acetylation	[1]
67	KMAQENPKMHNSEIS	acetylation	[1]
75	MHNSEISKRLGAEWK	acetylation	[1]
89	KLLSETEKRPFIDEA	acetylation	[1]
97	RPFIDEAKRLRALHM	acetylation	[1]
105	RLRALHMKEHPDYKY	acetylation	[1]
111	MKEHPDYKYRPRRKT	acetylation	[1]
117	YKYRPRRKTKTLMKK	acetylation	[1]
119	YRPRRKTKTLMKKDK	acetylation	[1]
123	RKTKTLMKKDKYTLP	acetylation	[1]
247	GSMGSVVKSEASSSP	sumoylation	[2, 3]

Reference

 [1] Acetylation of sox2 induces its nuclear export in embryonic stem cells.
 Baltus GA, Kowalski MP, Zhai H, Tutter AV, Quinn D, Wall D, Kadam S.
 Stem Cells. 2009 Sep;27(9):2175-84. [PMID: 19591226]
 [2] Inhibition of DNA binding of Sox2 by the SUMO conjugation.
 Tsuruzoe S, Ishihara K, Uchimura Y, Watanabe S, Sekita Y, Aoto T, Saitoh H, Yuasa Y, Niwa H, Kawasuji M, Baba H, Nakao M.
 Biochem Biophys Res Commun. 2006 Dec 29;351(4):920-6. [PMID: 17097055]
 [3] [Construction and expression of vector encoding Sox2 with mutated SUMO accepter site].
 Guo ZK, Wu XQ, Shan LR, Song Z.
 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Nov;25(11):967-9. [PMID: 19900357] 

Functional Description

 Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). 

Sequence Annotation

 DNA_BIND 43 111 HMG box.
 MOD_RES 253 253 Phosphoserine (By similarity).
 CROSSLNK 247 247 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Activator; Complete proteome; Developmental protein; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0021984; P:adenohypophysis development; IMP:MGI.
 GO:0021987; P:cerebral cortex development; IMP:MGI.
 GO:0050973; P:detection of mechanical stimulus involved in equilibrioception; IMP:MGI.
 GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IMP:MGI.
 GO:0048852; P:diencephalon morphogenesis; IMP:MGI.
 GO:0001714; P:endodermal cell fate specification; ISO:MGI.
 GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IDA:MGI.
 GO:0021879; P:forebrain neuron differentiation; IMP:MGI.
 GO:0042472; P:inner ear morphogenesis; IMP:MGI.
 GO:0060235; P:lens induction in camera-type eye; IGI:MGI.
 GO:0048286; P:lung alveolus development; IDA:MGI.
 GO:0030539; P:male genitalia development; IMP:MGI.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB.
 GO:0045665; P:negative regulation of neuron differentiation; IDA:MGI.
 GO:0045668; P:negative regulation of osteoblast differentiation; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0048663; P:neuron fate commitment; IMP:MGI.
 GO:0097150; P:neuronal stem cell maintenance; IGI:UniProtKB.
 GO:0030910; P:olfactory placode formation; IGI:MGI.
 GO:0046148; P:pigment biosynthetic process; IMP:MGI.
 GO:0030858; P:positive regulation of epithelial cell differentiation; IDA:MGI.
 GO:0002052; P:positive regulation of neuroblast proliferation; IMP:MGI.
 GO:0045666; P:positive regulation of neuron differentiation; IMP:MGI.
 GO:0045747; P:positive regulation of Notch signaling pathway; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0032526; P:response to retinoic acid; IDA:MGI.
 GO:0060042; P:retina morphogenesis in camera-type eye; IMP:MGI.
 GO:0043586; P:tongue development; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR009071; HMG_box_dom.
 IPR022097; TF_SOX. 

Pfam

 PF00505; HMG_box
 PF12336; SOXp 

SMART

 SM00398; HMG 

PROSITE

 PS50118; HMG_BOX_2 

PRINTS