UniProt Accession

 NOP58_YEAST; Q12499; D6W309 

Genbank Protein ID

 AF056070; X90565; Z75217; BK006948 

Genbank Nucleotide ID

 AAC39484.1; CAA62165.1; CAA99630.1; DAA11075.1 

Protein Name

 Nucleolar protein 58 

Protein Synonyms/Alias

 Nucleolar protein 5 

Gene Name

 NOP58 

Gene Synonyms/Alias

 NOP5; YOR310C; O6108 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
24	ASDKKIYKSSSLIQD	acetylation	[1]
93	TLIVSETKLANAINK	acetylation	[1]
281	NYLSARMKAIAPNLT	ubiquitination	[2, 3]
366	IARVLAAKAAVSLRY	ubiquitination	[3]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Required for pre-18S rRNA processing. May bind microtubules. 

Sequence Annotation

 DOMAIN 283 403 Nop.  

Keyword

 Coiled coil; Complete proteome; Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 511 AA 

Protein Sequence

Gene Ontology

 GO:0030686; C:90S preribosome; IDA:SGD.
 GO:0031428; C:box C/D snoRNP complex; IDA:SGD.
 GO:0032040; C:small-subunit processome; IDA:SGD.
 GO:0017069; F:snRNA binding; IDA:UniProtKB.
 GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0006608; P:snRNP protein import into nucleus; NAS:UniProtKB. 

Interpro

 IPR012974; NOP5_N.
 IPR002687; Nop_dom.
 IPR012976; NOSIC. 

Pfam

 PF01798; Nop
 PF08156; NOP5NT
 PF08060; NOSIC 

SMART

 SM00931; NOSIC 

PROSITE

 PS51358; NOP 

PRINTS