| Tag | Content |
|---|
| CPLM ID | CPLM-006330 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NADH-quinone oxidoreductase subunit C/D |
Protein Synonyms/Alias | NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D; NUO3/NUO4 |
Gene Name | nuoC |
Gene Synonyms/Alias | nuoCD; nuoD; b2286; JW5375 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 49 | GVPVVWIKREQLLEV | acetylation | [1] | | 61 | LEVGDFLKKLPKPYV | acetylation | [1] | | 62 | EVGDFLKKLPKPYVM | acetylation | [1] | | 65 | DFLKKLPKPYVMLFD | acetylation | [1] | | 125 | LHVPTFTKLFPNANW | acetylation | [1] | | 161 | IMMPQTWKGHPLRKD | acetylation | [1] | | 183 | FSPFELTKAKQDLEM | acetylation | [1] | | 196 | EMEALTFKPEEWGMK | acetylation | [1] | | 203 | KPEEWGMKRGTENED | acetylation | [1] | | 341 | FAFTDRQKIYDLVEA | acetylation | [1] | | 385 | EFLDWMPKRLASYEK | acetylation | [1] | | 392 | KRLASYEKAALQNTI | acetylation | [1] | | 413 | GVAAYGAKEALEWGT | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. |
Sequence Annotation | REGION 2 186 NADH dehydrogenase I subunit C.
REGION 210 596 NADH dehydrogenase I subunit D. |
Keyword | Cell inner membrane; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Multifunctional enzyme; NAD; Oxidoreductase; Quinone; Reference proteome; Transport; Ubiquinone. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 596 AA |
Protein Sequence | MTDLTAQEPA WQTRDHLDDP VIGELRNRFG PDAFTVQATR TGVPVVWIKR EQLLEVGDFL 60
KKLPKPYVML FDLHGMDERL RTHREGLPAA DFSVFYHLIS IDRNRDIMLK VALAENDLHV 120
PTFTKLFPNA NWYERETWDL FGITFDGHPN LRRIMMPQTW KGHPLRKDYP ARATEFSPFE 180
LTKAKQDLEM EALTFKPEEW GMKRGTENED FMFLNLGPNH PSAHGAFRIV LQLDGEEIVD 240
CVPDIGYHHR GAEKMGERQS WHSYIPYTDR IEYLGGCVNE MPYVLAVEKL AGITVPDRVN 300
VIRVMLSELF RINSHLLYIS TFIQDVGAMT PVFFAFTDRQ KIYDLVEAIT GFRMHPAWFR 360
IGGVAHDLPR GWDRLLREFL DWMPKRLASY EKAALQNTIL KGRSQGVAAY GAKEALEWGT 420
TGAGLRATGI DFDVRKARPY SGYENFDFEI PVGGGVSDCY TRVMLKVEEL RQSLRILEQC 480
LNNMPEGPFK ADHPLTTPPP KERTLQHIET LITHFLQVSW GPVMPANESF QMIEATKGIN 540
SYYLTSDGST MSYRTRVRTP SFAHLQQIPA AIRGSLVSDL IVYLGSIDFV MSDVDR 596 |
Gene Ontology | GO:0045272; C:plasma membrane respiratory chain complex I; IDA:EcoCyc. GO:0051287; F:NAD binding; IEA:InterPro. GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:EcoCyc. GO:0048038; F:quinone binding; IEA:UniProtKB-KW. GO:0006810; P:transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |