CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041927
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bromodomain and WD repeat domain containing 2, isoform CRA_a 
Protein Synonyms/Alias
 PH-interacting protein 
Gene Name
 Wdr11 
Gene Synonyms/Alias
 Brwd2; mCG_22163 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
764APGKGNQKLIAMYNDubiquitination[1]
898HALSNDIKKLLLDPDubiquitination[1]
899ALSNDIKKLLLDPDFubiquitination[1]
989RVNLQEVKRSTYDHTubiquitination[1]
1109EECADVLKRWVDHLCacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1223 AA 
Protein Sequence
MLPYTVNFKV SARTLTGALN AHNKAAVDWG WQGLIAYGCH SLVVVIDSNT AQTLQVLEKH 60
KADIVKVRWA RENYHHNIGS PYCLRLASAD VTGKIIVWDV AAGVAQCEIQ EHVKPIQDVQ 120
WLWNQDASRD LLLAIHPPNY IVLWNADTGT KLWKKSYADN ILSFSFDPFD PSHLTLLTSE 180
GIVFISDFSP SKPPSGPGKK VYISSPHSSP AHNKLAAATG AKKALNKVKI LITQEKPSAD 240
FVALNDCLQL AYLPSKRNHM LLLYPREILI LDLEVNQTVG VIAIERTGVP FLQVIPCSQR 300
DGLFCLHENG CITLRVRRSY NSICTTSNDE PDLDPVQELT YDLRSQCDAI RVTKTVRPFS 360
MVCCPVNENA AALIVSDGRV MIWELKSAVC SRNARNSSGV SPLYSPVSFC GIPGGVLQNK 420
LPDLSLDNMI GQSAIAGEEH PKGSILQEVH LKFLLTGLLS GLPSPQFAIR MCPPLTTKNI 480
KMYQPLLAVG TSNGSVLVYH LTSGLLHKEL SVHSCEVKGI EWTSLTSFLS FAASTPNNMG 540
LVRNELQLVD LPTGRSTAFR GDRGNDESPI EMIKVSHLKQ YLAVVFKDKP LELWDIRTCT 600
LLREMSKSFP AITALEWSPS HNLKSLRKKQ LATREAMARQ TVVSDAELGA VESSVISLLQ 660
EAESKAELSQ NISAREHFVF TDNDGQVYHL TVEGNSVKDS ARIPPDGSMG SITCIAWKGD 720
TLVLGDMDGN LNFWDLKARV SRGIPTHRSW VRKIRFAPGK GNQKLIAMYN DGAEVWDTKE 780
VQMVSSLRSG RNVTFRILDV DWCTSDKVIL ASDDGCIRVL EMSMKSTCFR MDEQELVEPV 840
WCPYLLVPRA ALALKAFLLH QPWNGRYSLD ISHIDYPENE EIKTLLQEQL HALSNDIKKL 900
LLDPDFSLLQ RCLLVSRLYG DESELHFWTV AAHYLHSLSQ AKSGDTVVTK EGAPKDRLSN 960
PLDICYDVLC ENTYFQKFQL ERVNLQEVKR STYDHTRKCT DQLLLLGQTD RAVQLLLETS 1020
ADNQHYYCDS LKACLVTTVT SSGPSQSTIK LVATNMIANG KLAEGVQLLC LIDKAADACR 1080
YLQTYGEWNR AAWLAKVRLN SEECADVLKR WVDHLCSPQV NQKSKALLVL LSLGCFVSVA 1140
ETLHSMRYFD RAALFVEACL KYGAFEVSED TEKLIAAIYA DYARSLKSLG FRQGAVRFAS 1200
KAGAAGRDLL NELGSTKEEL TES 1223 
Gene Ontology
 GO:0005929; C:cilium; IDA:MGI.
 GO:0005737; C:cytoplasm; ISO:MGI. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
  
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1 
PRINTS