| Tag | Content |
|---|
| CPLM ID | CPLM-008981 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cadherin-15 |
Protein Synonyms/Alias | Cadherin-14; Muscle cadherin; M-cadherin |
Gene Name | CDH15 |
Gene Synonyms/Alias | CDH14; CDH3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 637 | FWKQSRGKGLLHGPQ | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. |
Sequence Annotation | DOMAIN 61 152 Cadherin 1.
DOMAIN 153 260 Cadherin 2.
DOMAIN 261 375 Cadherin 3.
DOMAIN 376 481 Cadherin 4.
DOMAIN 482 590 Cadherin 5.
CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
CARBOHYD 531 531 N-linked (GlcNAc...) (Potential).
CARBOHYD 538 538 N-linked (GlcNAc...) (Potential).
CARBOHYD 576 576 N-linked (GlcNAc...) (Potential). |
Keyword | Calcium; Cell adhesion; Cell membrane; Chromosomal rearrangement; Cleavage on pair of basic residues; Complete proteome; Disease mutation; Glycoprotein; Membrane; Mental retardation; Metal-binding; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 814 AA |
Protein Sequence | MDAAFLLVLG LLAQSLCLSL GVPGWRRPTT LYPWRRAPAL SRVRRAWVIP PISVSENHKR 60
LPYPLVQIKS DKQQLGSVIY SIQGPGVDEE PRGVFSIDKF TGKVFLNAML DREKTDRFRL 120
RAFALDLGGS TLEDPTDLEI VVVDQNDNRP AFLQEAFTGR VLEGAVPGTY VTRAEATDAD 180
DPETDNAALR FSILQQGSPE LFSIDELTGE IRTVQVGLDR EVVAVYNLTL QVADMSGDGL 240
TATASAIITL DDINDNAPEF TRDEFFMEAI EAVSGVDVGR LEVEDRDLPG SPNWVARFTI 300
LEGDPDGQFT IRTDPKTNEG VLSIVKALDY ESCEHYELKV SVQNEAPLQA AALRAERGQA 360
KVRVHVQDTN EPPVFQENPL RTSLAEGAPP GTLVATFSAR DPDTEQLQRL SYSKDYDPED 420
WLQVDAATGR IQTQHVLSPA SPFLKGGWYR AIVLAQDDAS QPRTATGTLS IEILEVNDHA 480
PVLAPPPPGS LCSEPHQGPG LLLGATDEDL PPHGAPFHFQ LSPRLPELGR NWSLSQVNVS 540
HARLRPRHQV PEGLHRLSLL LRDSGQPPQQ REQPLNVTVC RCGKDGVCLP GAAALLAGGT 600
GLSLGALVIV LASALLLLVL VLLVALRARF WKQSRGKGLL HGPQDDLRDN VLNYDEQGGG 660
EEDQDAYDIS QLRHPTALSL PLGPPPLRRD APQGRLHPQP PRVLPTSPLD IADFINDGLE 720
AADSDPSVPP YDTALIYDYE GDGSVAGTLS SILSSQGDED QDYDYLRDWG PRFARLADMY 780
GHPCGLEYGA RWDHQAREGL SPGALLPRHR GRTA 814 |
Gene Ontology | GO:0005901; C:caveola; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031594; C:neuromuscular junction; IEA:Compara. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0034332; P:adherens junction organization; TAS:Reactome. GO:0007155; P:cell adhesion; TAS:ProtInc. GO:0034329; P:cell junction assembly; TAS:Reactome. GO:0007156; P:homophilic cell adhesion; IEA:InterPro. GO:0042692; P:muscle cell differentiation; TAS:Reactome. GO:0051149; P:positive regulation of muscle cell differentiation; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |