UniProt Accession

 B5MCZ6_HUMAN; B5MCZ6 

Genbank Protein ID

 AC007250 

Genbank Nucleotide ID

  

Protein Name

 E3 ubiquitin-protein ligase FANCL 

Protein Synonyms/Alias

  

Gene Name

 FANCL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
144	LGADHVVKPLGIKLS	ubiquitination	[1, 2]
149	VVKPLGIKLSRNIHL	ubiquitination	[1, 2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 258 AA 

Protein Sequence

Gene Ontology

 GO:0043240; C:Fanconi anaemia nuclear complex; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:GOC. 

Interpro

 IPR026848; Fancl.
 IPR019162; FancL_WD-rpt_cont_dom.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF09765; WD-3 

SMART

 SM00184; RING 

PROSITE

  

PRINTS