| Tag | Content |
|---|
| CPLM ID | CPLM-020417 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | UBX domain-containing protein 6 |
Protein Synonyms/Alias | UBX domain-containing protein 1 |
Gene Name | UBXN6 |
Gene Synonyms/Alias | UBXD1; UBXDC2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 32 | TIRNQVRKELQAEAT | ubiquitination | [1] | | 119 | NKDQDRVKLGVDTIA | ubiquitination | [1] | | 127 | LGVDTIAKYLDNIHL | ubiquitination | [1] | | 248 | NLTAEEIKREQRLRS | ubiquitination | [1] | | 377 | AEPDSILKPELLSAI | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation. |
Sequence Annotation | DOMAIN 175 244 PUB.
DOMAIN 332 408 UBX.
MOD_RES 96 96 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 441 AA |
Protein Sequence | MAAAAALARL EQKQSRAWGP TSQDTIRNQV RKELQAEATV SGSPEAPGTN VVSEPREEGS 60
AHLAVPGVYF TCPLTGATLR KDQRDACIKE AILLHFSTDP VAASIMKIYT FNKDQDRVKL 120
GVDTIAKYLD NIHLHPEEEK YRKIKLQNKV FQERINCLEG THEFFEAIGF QKVLLPAQDQ 180
EDPEEFYVLS ETTLAQPQSL ERHKEQLLAA EPVRAKLDRQ RRVFQPSPLA SQFELPGDFF 240
NLTAEEIKRE QRLRSEAVER LSVLRTKAMR EKEEQRGLRK YNYTLLRVRL PDGCLLQGTF 300
YARERLGAVY GFVREALQSD WLPFELLASG GQKLSEDENL ALNECGLVPS ALLTFSWDMA 360
VLEDIKAAGA EPDSILKPEL LSAIEKLL 388 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |