UniProt Accession

 AGPD1_HUMAN; A2RU49; B7ZMA5; Q6ZTN0 

Genbank Protein ID

 AK126453; AC027228; CH471136; BC132753; BC144383 

Genbank Nucleotide ID

 BAC86556.1; EAW99167.1; AAI32754.1; AAI44384.1 

Protein Name

 Hydroxylysine kinase 

Protein Synonyms/Alias

 5-hydroxy-L-lysine kinase; Aminoglycoside phosphotransferase domain-containing protein 1 

Gene Name

 AGPHD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
179	ENFIWNLKNVPLLEK	ubiquitination	[1]
186	KNVPLLEKYLYALGQ	ubiquitination	[2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Catalyzes the GTP-dependent phosphorylation of 5- hydroxy-L-lysine. 

Sequence Annotation

 ACT_SITE 226 226 Proton acceptor (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 373 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0047992; F:hydroxylysine kinase activity; IEA:EC. 

Interpro

 IPR002575; Aminoglycoside_PTrfase.
 IPR011009; Kinase-like_dom. 

Pfam

 PF01636; APH 

SMART

  

PROSITE

  

PRINTS