UniProt Accession

 CAPZB_MOUSE; P47757; A2AMV7 

Genbank Protein ID

 U10406; U10407; FJ692320; AL807811 

Genbank Nucleotide ID

 AAA52226.1; AAA52227.1; ACN43612.1 

Protein Name

 F-actin-capping protein subunit beta 

Protein Synonyms/Alias

 CapZ beta 

Gene Name

 Capzb 

Gene Synonyms/Alias

 Cappb1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
254	DAIPDNHKFKQLQRE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Isoform 3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 182 182 Phosphoserine.
 MOD_RES 235 235 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin capping; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IDA:MGI.
 GO:0033150; C:cytoskeletal calyx; IEA:UniProtKB-SubCell.
 GO:0008290; C:F-actin capping protein complex; IDA:MGI.
 GO:0014704; C:intercalated disc; IDA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0071203; C:WASH complex; ISS:UniProtKB.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0051016; P:barbed-end actin filament capping; IDA:MGI.
 GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
 GO:0030032; P:lamellipodium assembly; IMP:MGI.
 GO:0048747; P:muscle fiber development; IMP:MGI.
 GO:0031115; P:negative regulation of microtubule polymerization; IDA:MGI.
 GO:0031175; P:neuron projection development; IMP:MGI.
 GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
 GO:0090036; P:regulation of protein kinase C signaling cascade; IMP:MGI. 

Interpro

 IPR019771; F-actin_capping_bsu_CS.
 IPR001698; WASH_F-actin_cap_beta. 

Pfam

 PF01115; F_actin_cap_B 

SMART

  

PROSITE

 PS00231; F_ACTIN_CAPPING_BETA 

PRINTS

 PR00192; FACTINCAPB.