| Tag | Content |
|---|
| CPLM ID | CPLM-014085 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 468 |
Protein Synonyms/Alias | |
Gene Name | ZNF468 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 166 | KIGNQVEKSINNASS | ubiquitination | [1] | | 191 | PKTHISNKYGNNSLH | ubiquitination | [1] | | 250 | CKCDVCGKVFNQKRY | ubiquitination | [1] | | 297 | KALHTGEKPYECEEC | ubiquitination | [1] | | 330 | GEKPYKCKVCDEAFA | ubiquitination | [1] | | 353 | TILHTGEKPYTCNEC | ubiquitination | [1] | | 384 | HTGEKPYKCEECDKV | ubiquitination | [1] | | 412 | HSGEKPYKCEECCKV | ubiquitination | [1] | | 496 | HTGEKPYKCNECGKT | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May be involved in transcriptional regulation. |
Sequence Annotation | DOMAIN 8 80 KRAB.
ZN_FING 215 237 C2H2-type 1; degenerate.
ZN_FING 243 265 C2H2-type 2.
ZN_FING 271 293 C2H2-type 3.
ZN_FING 299 321 C2H2-type 4.
ZN_FING 327 349 C2H2-type 5.
ZN_FING 355 377 C2H2-type 6.
ZN_FING 383 405 C2H2-type 7.
ZN_FING 411 433 C2H2-type 8.
ZN_FING 439 461 C2H2-type 9.
ZN_FING 467 489 C2H2-type 10.
ZN_FING 495 517 C2H2-type 11. |
Keyword | Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 522 AA |
Protein Sequence | MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMLKTLSS 60
TGQGNTEVIH TGTLHRQASH HIGEFCFHEI EKDIHGFEFQ WKEDETNGHA APMTEIKELA 120
GSTGQHDQRH AGNKRIKDQL GSSFHLHLPE PHIFQSEGKI GNQVEKSINN ASSVSTSQRI 180
CCRPKTHISN KYGNNSLHSS LLTQKWEVHM REKSFECIQS FKSFNCSSLL KKHQIIHLEE 240
KQCKCDVCGK VFNQKRYLAC HRRCHTGEKP YKCNECGKTF GHNSSLFIHK ALHTGEKPYE 300
CEECDKVFSR KSHLERHKRI HTGEKPYKCK VCDEAFAYNS YLAKHTILHT GEKPYTCNEC 360
GKVFNRLSTL ARHHRLHTGE KPYKCEECDK VFSRKSHLER HRRIHSGEKP YKCEECCKVF 420
SRKSNLERHR RIHTGEKPYK CKVCDKAFQR DSHLAQHQRV HTGEKPYKCN ECGKTFGQTS 480
SLIIHRRLHT GEKPYKCNEC GKTFSQMSSL VYHHRLHSGE KP 522 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |