UniProt Accession

 AHP1_YEAST; P38013; D6VYA9 

Genbank Protein ID

 X89514; Z73281; U53878; BK006945 

Genbank Nucleotide ID

 CAA61687.1; CAA97676.1; AAB67554.1; DAA09425.1 

Protein Name

 Peroxiredoxin type-2 

Protein Synonyms/Alias

 AHPC1; Cytoplasmic thiol peroxidase 3; cTPx 3; Peroxiredoxin type II; Peroxisomal alkyl hydroperoxide reductase; TPx type II; Thiol-specific antioxidant II; TSA II; Thioredoxin peroxidase type II; Thioredoxin reductase type II 

Gene Name

 AHP1 

Gene Synonyms/Alias

 YLR109W; L2916; L9354.5 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
8	MSDLVNKKFPAGDYK	ubiquitination	[1]
32	DADSESCKMPQTVEW	acetylation	[2]
32	DADSESCKMPQTVEW	ubiquitination	[1]
41	PQTVEWSKLISENKK	acetylation	[2]
48	KLISENKKVIITGAP	ubiquitination	[1, 3]
102	FANQAWAKSLGVKDT	ubiquitination	[1]
107	WAKSLGVKDTTHIKF	acetylation	[2]
107	WAKSLGVKDTTHIKF	ubiquitination	[1]
113	VKDTTHIKFASDPGC	acetylation	[2]
113	VKDTTHIKFASDPGC	ubiquitination	[1, 3]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Thiol-specific antioxidant protein with alkyl hydroperoxidase activity. Involved in osmotic stress resistance and detoxification of the cell. Preferentially eliminates organic peroxides rather than H(2)O(2). Involved in cellular Mn(2+) homeostasis. 

Sequence Annotation

 DOMAIN 9 176 Thioredoxin.
 ACT_SITE 62 62 Cysteine sulfenic acid (-SOH)
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 28 28 Phosphoserine.
 MOD_RES 59 59 Phosphoserine.
 MOD_RES 116 116 Phosphoserine.
 DISULFID 62 62 Interchain (with C-120); in linked form.
 DISULFID 120 120 Interchain (with C-62); in linked form.  

Keyword

 3D-structure; Acetylation; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 176 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0008379; F:thioredoxin peroxidase activity; IDA:SGD.
 GO:0045454; P:cell redox homeostasis; IMP:SGD.
 GO:0034599; P:cellular response to oxidative stress; IGI:SGD.
 GO:0010038; P:response to metal ion; IMP:SGD. 

Interpro

 IPR013740; Redoxin.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF08534; Redoxin 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS