CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004931
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histidine ammonia-lyase 
Protein Synonyms/Alias
 Histidase 
Gene Name
 Hal 
Gene Synonyms/Alias
 Huth 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
112SKYREPEKYIALDGDacetylation[1]
158EVIDSIIKERTVVYGacetylation[1]
182RTVIPANKLQELQVNacetylation[1]
293VLEAHGLKPIVLKPKacetylation[1]
298GLKPIVLKPKEGLALacetylation[1]
592SVVRPWIKDRFMAPDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 MOD_RES 254 254 2,3-didehydroalanine (Ser) (By
 MOD_RES 631 631 Phosphoserine (By similarity).
 MOD_RES 635 635 Phosphoserine (By similarity).
 MOD_RES 648 648 Phosphoserine (By similarity).
 CROSSLNK 253 255 5-imidazolinone (Ala-Gly) (By  
Keyword
 Complete proteome; Direct protein sequencing; Histidine metabolism; Lyase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 657 AA 
Protein Sequence
MPRYTVHVRG EWLAVPCQDG KLSVGWLGRE AVRRYMKNKP DNGGFTSVDE VRFLVRRCKG 60
LGLLDNEDLL EVALEDNEFV EVVIEGDVMS PDFIPSQPEG VFLYSKYREP EKYIALDGDS 120
LSTEDLVNLG KGHYKIKLTS IAEKKVQQSR EVIDSIIKER TVVYGITTGF GKFARTVIPA 180
NKLQELQVNL VRSHSSGVGK PLSPERCRML LALRINVLAK GYSGISLETL KQVIEVFNAS 240
CLSYVPEKGT VGASGDLAPL SHLALGLIGE GKMWSPKSGW ADAKYVLEAH GLKPIVLKPK 300
EGLALINGTQ MITSLGCEAV ERASAIARQA DIVAALTLEV LKGTTKAFDT DIHAVRPHRG 360
QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC PQVHGVVNDT IAFVKDIITT 420
ELNSATDNPM VFASRGETIS GGNFHGEYPA KALDYLAIGV HELAAISERR IERLCNPSLS 480
ELPAFLVAEG GLNSGFMIAH CTAAALVSES KALCHPSSVD SLSTSAATED HVSMGGWAAR 540
KALRVIEHVE QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI 600
EAAHRLLLDQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LESLRKNSAT IPESDDL 657 
Gene Ontology
 GO:0005829; C:cytosol; TAS:RGD.
 GO:0004397; F:histidine ammonia-lyase activity; IDA:RGD.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
 GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
 GO:0006547; P:histidine metabolic process; TAS:RGD. 
Interpro
 IPR001106; Aromatic_Lyase.
 IPR024083; Fumarase/histidase_N.
 IPR005921; HutH.
 IPR008948; L-Aspartase-like.
 IPR022313; Phe/His_NH3-lyase_AS. 
Pfam
 PF00221; Lyase_aromatic 
SMART
  
PROSITE
 PS00488; PAL_HISTIDASE 
PRINTS