CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017864
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family A member 3 
Protein Synonyms/Alias
  
Gene Name
 Abca3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
503NPRTVVGKEEEGSDPubiquitination[1]
512EEGSDPEKALRNEYFubiquitination[1]
531EDLVAGIKIKHLSKVubiquitination[1]
640LKGLSLQKCPEEVKQubiquitination[1]
646QKCPEEVKQMLHILSubiquitination[1]
711WDLLQQQKSDRTVLLubiquitination[1]
812RFESLFAKLEKKQKEubiquitination[1]
841EVFLRVGKLVDTSMDubiquitination[1]
1408RISLAVQKGECFGLLubiquitination[1]
1422LGFNGAGKTTTFKMLubiquitination[1]
1604SPQHLKSKFGSGYSLubiquitination[1]
1620AKVRSEGKQDALEEFubiquitination[1]
1668KVFGILEKAKEKYGVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol (By similarity). 
Sequence Annotation
 DOMAIN 530 763 ABC transporter 1.
 DOMAIN 1381 1614 ABC transporter 2.
 NP_BIND 566 573 ATP 1 (Potential).
 NP_BIND 1416 1423 ATP 2 (Potential).  
Keyword
 ATP-binding; Complete proteome; Membrane; Nucleotide-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1704 AA 
Protein Sequence
MAVLRQLTLL LWKNYTLKKR KVLVTVLELF LPLLFSGILI WLRLKIQSEN VPNATVYPDQ 60
SIQELPLFFS FPPPGGTWEL AYVPSHSDAA RTITETVKRE FMIKMRVHGF SSEKDFEDYI 120
RYDNHSSSVL AAVVFEHSFN HSQDPLPLAV KYHLRFSYTR RNYMWTQTGN IFLKETEGWH 180
TTSLFPLFPS PGPREPSSPD GGEPGYIREG FLAMQHAVDK AIMRYHANTS AQQLFQKLMV 240
ITKRFPFPPY ISDPFLIAIQ YQLPLLLMLS FTYTSLTIIR AVVQEKEKKL KEYMRMMGLN 300
SWLHWSAWFL MFFLFFLIVV SFMTLLFCVK VKKDIAVLSN SDPSLVLAFL LCFAISSISF 360
SFMVSTFFSK ANIAAAVGGF LYFFTYTPYF FVAPRYNWMT LSQKLLSCLL SNVAMAMGAQ 420
LIGKFEAKGT GIQWRDLLNP VNVDDNFCFG QVLGMLLLDS ALYGLVTWYV EAVFPGQFGV 480
PQPWHFFLMP SYWCGNPRTV VGKEEEGSDP EKALRNEYFE AEPEDLVAGI KIKHLSKVFQ 540
VGNKDKMGIR DLTLNLYEGQ ITVLLGHNGA GKTTTMSLLT GLFPPTSGHA YIHGYEISQD 600
MAQIRKSLGL CPQHDVLFDN LTVAEHLYFY AQLKGLSLQK CPEEVKQMLH ILSLEDKRDL 660
RSKFLSGGMK RKLSIGIALI AGSKVLMLDE PTSGMDAVSR RAIWDLLQQQ KSDRTVLLTT 720
HFMDEADLLG DRIAILAKGE LQCCGSSLFL KQKYGAGYHM TLVKEPHCNP EGISQLVHHH 780
VPNAMLESHA GAELSFILPK ESTHRFESLF AKLEKKQKEL GIASFGASVT TMEEVFLRVG 840
KLVDTSMDIQ AIQLPALQYQ HERRASDWAL DSNLCGVMDP TNGIGALIEE EEVLVKLNTG 900
LALHCQQFWA MFLKKAAYSW REWKMVAAQV LVPLTCLTLA LLAIHYTSEI FDDPLLKLSL 960
NEYGRTVVPF SVPGTSRLAQ QLSENLRDML QAERQEPREV LGDLEEFLVF RASVEGGGFN 1020
ERCLVATSFK DRGELTVVTA LFNNQAYHSP ATALAIVDNL LFKLLCGPQA SIEISNYPQP 1080
RNTLQVAKDH FNEGRKGFDI ALNLLIAMAF LASTFSILAV SERAVQAKHV QFVSGVHVAT 1140
FWFSALLWDL ISFLVPSLLL LVVFQAFNVH AFTRDGHMAD LLLLLMLYGW AIIPLMYLMS 1200
FFFSAASTAY TRLTIFNILS GIATFIMVTI MRIPAVKLEE LSRTLDHVFL VLPNHCLGMA 1260
VSNFYENYET RRYCTSSELA AHYCKKYNIQ YQESFYAWST PGVGKFVTSM AASGGIYLTL 1320
LFLIETNLLW RLRTFICAFR RRWTLAELQN RTSVLPEDQD VAEERSRILV PSLDSMLDTP 1380
LIINELSKVY DQRAPLLAVD RISLAVQKGE CFGLLGFNGA GKTTTFKMLT GEETITSGDA 1440
FVGGYSISSD IGKVRQRMGY CPQFDALLDH MTGREMLVMY ARLRGIPERL INACVENTLR 1500
GLLLEPHANK LVKTYSGGNK RKLSTGIALI GEPAVIFLDE PSTGMDPVAR RLLWDTVARA 1560
RESGKAIVIT SHSMEECEAL CTRLAIMVQG QFKCLGSPQH LKSKFGSGYS LQAKVRSEGK 1620
QDALEEFKAF VDLTFPGSIL EDEHQDMVHY HLPGCDLSWA KVFGILEKAK EKYGVDDYSV 1680
SQISLEQVFL SFAHLQPPTT EDGR 1704 
Gene Ontology
 GO:0097233; C:alveolar lamellar body membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR026969; ABCA3.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS