UniProt Accession

 PHS2_HUMAN; Q9H0N5; Q8TD40 

Genbank Protein ID

 AL136721; AC006077; AC008670; BC054021; AF499009 

Genbank Nucleotide ID

 CAB66655.1; AAH54021.1; AAM18136.1 

Protein Name

 Pterin-4-alpha-carbinolamine dehydratase 2 

Protein Synonyms/Alias

 PHS 2; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; DcoH-like protein DCoHm; Dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor 

Gene Name

 PCBD2 

Gene Synonyms/Alias

 DCOH2; DCOHM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
125	KLAKFIEKAAASV**	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Lyase; Reference proteome; Tetrahydrobiopterin biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 130 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:EC.
 GO:0004505; F:phenylalanine 4-monooxygenase activity; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR001533; Trans/pterin_deHydtase. 

Pfam

 PF01329; Pterin_4a 

SMART

  

PROSITE

  

PRINTS