| Tag | Content |
|---|
| CPLM ID | CPLM-003628 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar protein-sorting-associated protein 36 |
Protein Synonyms/Alias | ELL-associated protein of 45 kDa; ESCRT-II complex subunit VPS36 |
Gene Name | Vps36 |
Gene Synonyms/Alias | Eap45 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 107 | SSKNSYIKLSFKEHG | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3 (By similarity). |
Sequence Annotation | DOMAIN 1 88 GLUE N-terminal.
DOMAIN 105 138 GLUE C-terminal. |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Lipid-binding; Membrane; Nucleus; Protein transport; Reference proteome; Transcription; Transcription regulation; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 386 AA |
Protein Sequence | MDRFVWTSGL LEINETLVIQ QRGVRVYDGE EKIKFDAGTL LLSTHRLIWR DQKNNECCMA 60
IPLSQIVFIE EQAAGIGKSA KIVVHLHPAP PNKEPGPFQS SKNSYIKLSF KEHGQIEFYR 120
RLSEEMTQRR WETVPVSQSL QTKKGPQPGR IRAVGIVGIE RKLEEKRKET DKNISEAFED 180
LSKLMIQAKE MVELSKSIAN KIKEKQGDVT EDETIRFKSY LLSMGIANPV TRETYGSGTQ 240
YHMQLAKQLA GILQAPLEER GGIMSLTEVY CLVNRARGME LLSPEDLVNA CKMLEGLKLP 300
VRLRVFDSGV MVIELQTHKE EEMVASALET VSERGSLTSE EFAKLVGMSV LLAKERLLLA 360
EKMGHLCRDD SVEGLRFYPN LFMTQN 386 |
Gene Ontology | GO:0005768; C:endosome; ISS:UniProtKB. GO:0005770; C:late endosome; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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PROSITE | |
PRINTS | |