UniProt Accession

 CALB1_RAT; P07171 

Genbank Protein ID

 M31178; X04280; M27839; BC081764 

Genbank Nucleotide ID

 AAA40851.1; CAA27828.1; AAA40852.1; AAH81764.1 

Protein Name

 Calbindin 

Protein Synonyms/Alias

 Calbindin D28; D-28K; Spot 35 protein; Vitamin D-dependent calcium-binding protein, avian-type 

Gene Name

 Calb1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
133	FLKDLLEKANKTVDD	acetylation	[1]
136	DLLEKANKTVDDTKL	acetylation	[1]
142	NKTVDDTKLAEYTDL	acetylation	[1]
161	FDSNNDGKLELTEMA	acetylation	[1]
246	MALSDGGKLYRTDLA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. 

Sequence Annotation

 DOMAIN 11 46 EF-hand 1.
 DOMAIN 53 88 EF-hand 2.
 DOMAIN 98 133 EF-hand 3.
 DOMAIN 142 177 EF-hand 4.
 DOMAIN 186 221 EF-hand 5.
 REGION 2 7 Interaction with RANBP9 (By similarity).
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Calcium; Complete proteome; Direct protein sequencing; Metal-binding; Reference proteome; Repeat; Vitamin D. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:BHF-UCL.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005509; F:calcium ion binding; IDA:RGD.
 GO:0005499; F:vitamin D binding; IEA:UniProtKB-KW.
 GO:0071310; P:cellular response to organic substance; IEA:Compara.
 GO:0051480; P:cytosolic calcium ion homeostasis; IDA:RGD.
 GO:0007611; P:learning or memory; IEP:RGD.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0072205; P:metanephric collecting duct development; IEA:Compara.
 GO:0072286; P:metanephric connecting tubule development; IEA:Compara.
 GO:0072221; P:metanephric distal convoluted tubule development; IEA:Compara.
 GO:0035502; P:metanephric part of ureteric bud development; IEA:Compara.
 GO:0048167; P:regulation of synaptic plasticity; IMP:RGD.
 GO:0010842; P:retina layer formation; IEA:Compara.
 GO:0042359; P:vitamin D metabolic process; TAS:RGD. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13405; EF_hand_4
 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS