UniProt Accession

 LSM4_YEAST; P40070; D3DM18; Q07091 

Genbank Protein ID

 X82649; M97918; U18916; BK006939 

Genbank Nucleotide ID

 CAA57975.1; AAA58257.1; AAC03210.1; DAA07772.1 

Protein Name

 U6 snRNA-associated Sm-like protein LSm4 

Protein Synonyms/Alias

  

Gene Name

 LSM4 

Gene Synonyms/Alias

 SDB23; USS1; YER112W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
88	LQDNIIDKVKQQINS	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic LSM1-LSM7 complex which is thought to be involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple spliceosome snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping. LSM4 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre- rRNAs and U3 snoRNA. LSM4, probably in a complex that contains LSM2-LSM7 but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA. LSM4 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding; rRNA processing; Spliceosome; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 187 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0005732; C:small nucleolar ribonucleoprotein complex; IPI:SGD.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:SGD.
 GO:0005688; C:U6 snRNP; IDA:SGD.
 GO:0017070; F:U6 snRNA binding; IMP:SGD.
 GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:SGD.
 GO:0000398; P:mRNA splicing, via spliceosome; IPI:SGD.
 GO:0000956; P:nuclear-transcribed mRNA catabolic process; TAS:SGD.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR027141; LSm4/Sm_D1/D3.
 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc. 

Pfam

 PF01423; LSM 

SMART

 SM00651; Sm 

PROSITE

  

PRINTS