| Tag | Content |
|---|
| CPLM ID | CPLM-013263 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ceramide kinase-like protein |
Protein Synonyms/Alias | |
Gene Name | CERKL |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 275 | ALLLRAQKNAGMETD | methylation | [1] |
|
Reference | [1] Large-scale global identification of protein lysine methylation in vivo. Cao XJ, Arnaudo AM, Garcia BA. Epigenetics. 2013 May 1;8(5):477-85. [ PMID: 23644510] |
Functional Description | Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. |
Sequence Annotation | DOMAIN 164 339 DAGKc.
MOTIF 2 9 Nuclear localization signal 1
MOTIF 102 106 Nuclear localization signal 2. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Endoplasmic reticulum; Golgi apparatus; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Retinitis pigmentosa. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 558 AA |
Protein Sequence | MPWRRRRNRV SALEGGREEE APPEAAAVPP ALLTSPQQTE AAAERILLRG IFEIGRDSCD 60
VVLSERALRW RPIQPERPAG DSKYDLLCKE EFIELKDIFS VKLKRRCSVK QQRSGTLLGI 120
TLFICLKKEQ NKLKNSTLDL INLSEDHCDI WFRQFKKILA GFPNRPKSLK ILLNPQSHKK 180
EATQVYYEKV EPLLKLAGIK TDVTIMEYEG HALSLLKECE LQGFDGGHRK PLFAIHWSVQ 240
RLFTGMQTLE PSVVCVGGDG SASEVAHALL LRAQKNAGME TDRILTPVRA QLPLGLIPAG 300
STNVLAHSLH GVPHVITATL HIIMGHVQLV DVCTFSTAGK LLRFGFSAMF GFGGRTLALA 360
EKYRWMSPNQ RRDFAVVKAL AKLKAEDCEI SFLPFNSSDD VQERRAQGSP KSDCNDQWQM 420
IQGQFLNVSI MAIPCLCSVA PRGLAPNTRL NNGSMALIIA RNTSRPEFIK HLKRYASVKN 480
QFNFPFVETY TVEEVKVHPR NNTGGYNPEE EEDETASENC FPWNVDGDLM EVASEVHIRL 540
HPRLISLYGG SMEEMIPK 558 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB. GO:0005794; C:Golgi apparatus; IDA:UniProtKB. GO:0005730; C:nucleolus; IDA:UniProtKB. GO:0004143; F:diacylglycerol kinase activity; IEA:InterPro. GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB. GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |