UniProt Accession

 PSMD7_MOUSE; P26516; Q3TW61; Q8C0I8 

Genbank Protein ID

 M64641; M64640; M64634; M64635; M64636; M64637; M64639; AK031013; AK159825 

Genbank Nucleotide ID

 AAA39730.1; AAA39731.1; AAA39731.1; AAA39731.1; AAA39731.1; AAA39731.1; AAA39731.1; BAC27212.1; BAE35405.1 

Protein Name

 26S proteasome non-ATPase regulatory subunit 7 

Protein Synonyms/Alias

 26S proteasome regulatory subunit RPN8; 26S proteasome regulatory subunit S12; Mov34 protein; Proteasome subunit p40 

Gene Name

 Psmd7 

Gene Synonyms/Alias

 Mov-34; Mov34 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
45	VLLGSWQKKVLDVSN	acetylation	[1, 2]
45	VLLGSWQKKVLDVSN	succinylation	[2]
45	VLLGSWQKKVLDVSN	ubiquitination	[3]
100	GWYHTGPKLHKNDIA	ubiquitination	[3]
103	HTGPKLHKNDIAINE	ubiquitination	[3]
180	EHLLRDIKDTTVGTL	ubiquitination	[3]
199	TNQVHGLKGLNSKLL	ubiquitination	[3]
204	GLKGLNSKLLDIRSY	acetylation	[4]
214	DIRSYLEKVASGKLP	acetylation	[1]
279	LHNLINNKIANRDAE	acetylation	[1]
279	LHNLINNKIANRDAE	ubiquitination	[3]
313	KEKSDAAKKEEKKEK	acetylation	[5]
314	EKSDAAKKEEKKEKK	acetylation	[5]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays an essential role during mouse embryonic development. 

Sequence Annotation

 DOMAIN 4 118 MPN.
 MOD_RES 204 204 N6-acetyllysine (By similarity).
 MOD_RES 214 214 N6-acetyllysine (By similarity).
 CROSSLNK 180 180 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Isopeptide bond; Proteasome; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 321 AA 

Protein Sequence

Gene Ontology

 GO:0000502; C:proteasome complex; IEA:UniProtKB-KW. 

Interpro

 IPR000555; JAB1_Mov34_MPN_PAD1.
 IPR024969; Rpn11/EIF3F_C. 

Pfam

 PF01398; JAB
 PF13012; MitMem_reg 

SMART

 SM00232; JAB_MPN 

PROSITE

  

PRINTS