CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013326
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
 AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81993.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81995.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81996.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; AAY81997.1; BAE22007.1; CAM23372.1; AAH60648.1 
Protein Name
 Endothelin-converting enzyme 1 
Protein Synonyms/Alias
 ECE-1 
Gene Name
 Ece1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
17RGSFFLGKRGPGLMVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Converts big endothelin-1 to endothelin-1 (By similarity). 
Sequence Annotation
 ACT_SITE 607 607 By similarity.
 ACT_SITE 670 670 Proton donor (By similarity).
 METAL 606 606 Zinc; catalytic (By similarity).
 METAL 610 610 Zinc; catalytic (By similarity).
 METAL 666 666 Zinc; catalytic (By similarity).
 MOD_RES 24 24 Phosphothreonine (By similarity).
 CARBOHYD 165 165 N-linked (GlcNAc...).
 CARBOHYD 186 186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 209 209 N-linked (GlcNAc...).
 CARBOHYD 246 246 N-linked (GlcNAc...); atypical.
 CARBOHYD 250 250 N-linked (GlcNAc...); atypical.
 CARBOHYD 269 269 N-linked (GlcNAc...) (Potential).
 CARBOHYD 315 315 N-linked (GlcNAc...).
 CARBOHYD 361 361 N-linked (GlcNAc...).
 CARBOHYD 382 382 N-linked (GlcNAc...).
 CARBOHYD 383 383 N-linked (GlcNAc...); atypical.
 CARBOHYD 538 538 N-linked (GlcNAc...) (Potential).
 CARBOHYD 631 631 N-linked (GlcNAc...) (Potential).
 CARBOHYD 650 650 N-linked (GlcNAc...) (Potential).
 DISULFID 427 427 Interchain (By similarity).  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Membrane; Metal-binding; Metalloprotease; Phosphoprotein; Protease; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 769 AA 
Protein Sequence
MPPQSLGLQR GSFFLGKRGP GLMVSLPLLA SSLQVNFRSS RSGQRCWAAR TSVEKRLVVL 60
VTLLAAGLVA CLAALGIQYQ TRTPPVCLTE ACVSVTSSIL NSMDPTVDPC QDFFSYACGG 120
WIKANPVPDG HSRWGTFSNL WEHNQAVIKH LLENATASVS EAERKAQVYY RACMNETRIE 180
ELRAKPLMEL IEKLGGWNIT GPWAKDNFQD TLQVVTAHYR TSPFFSVYVS ADSKNSNSNV 240
IQVDQSGLGL PSRDYYLNKT ENEKVLTGYL NYMVQLGKLL GGGDEDAIRP QMQQILDFET 300
ALANITIPQE KRRDEELIYH KVTAAELQTL APAINWLPFL NTIFYPVEIN ESEPIVVYDK 360
EYLRQVSTLI NNTDKCLLNN YMMWNLVRKT SSFLDQRFQD ADEKFMEVMY GTKKTCIPRW 420
KFCVSDTENN LGFALGPMFV KATFAEDSKN IASEIIMEIK KAFEESLSTL KWMDEETRRS 480
AKEKADAIYN MIGYPNFIMD PKELDKVFND YTAVPDLYFE NAMRFFNFSW RVTADQLRKA 540
PNRDQWSMTP PMVNAYYSPT KNEIVFPAGI LQAPFYTRSS PNALNFGGIG VVVGHELTHA 600
FDDQGREYDK DGNLRPWWKN SSVEAFKQQT ECMVQQYSNY SVNGEPVNGR HTLGENIADN 660
GGLKAAYRAY QNWVKKNGAE QTLPTLGLTS NQLFFLGFAQ VWCSVRTPES SHEGLITDPH 720
SPSRFRVIGS LSNSKEFSEH FRCPPGSPMN PHHKCEVW 758 
Gene Ontology
 GO:0009986; C:cell surface; ISS:MGI.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005794; C:Golgi apparatus; ISS:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0033093; C:Weibel-Palade body; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0010815; P:bradykinin catabolic process; IEA:Compara.
 GO:0010816; P:calcitonin catabolic process; IEA:Compara.
 GO:0043583; P:ear development; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0034959; P:endothelin maturation; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0016486; P:peptide hormone processing; ISS:MGI.
 GO:0060037; P:pharyngeal system development; IMP:MGI.
 GO:0001921; P:positive regulation of receptor recycling; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0010814; P:substance P catabolic process; IEA:Compara. 
Interpro
 IPR024079; MetalloPept_cat_dom.
 IPR000718; Peptidase_M13.
 IPR018497; Peptidase_M13_C.
 IPR008753; Peptidase_M13_N. 
Pfam
 PF01431; Peptidase_M13
 PF05649; Peptidase_M13_N 
SMART
  
PROSITE
 PS00142; ZINC_PROTEASE 
PRINTS
 PR00786; NEPRILYSIN.