CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013803
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tubulin-specific chaperone cofactor E-like protein 
Protein Synonyms/Alias
 EL; Leucine-rich repeat-containing protein 35 
Gene Name
 TBCEL 
Gene Synonyms/Alias
 LRRC35 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
236LRSISLHKSGLQSWEubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Acts as a regulator of tubulin stability. 
Sequence Annotation
 REPEAT 73 98 LRR 1.
 REPEAT 99 123 LRR 2.
 REPEAT 124 147 LRR 3.
 REPEAT 150 172 LRR 4.
 REPEAT 173 197 LRR 5.
 REPEAT 199 224 LRR 6.
 REPEAT 226 250 LRR 7.
 DOMAIN 262 303 LRRCT.
 DOMAIN 334 424 Ubiquitin-like.
 MOD_RES 41 41 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 424 AA 
Protein Sequence
MDQPSGRSFM QVLCEKYSPE NFPYRRGPGM GVHVPATPQG SPMKDRLNLP SVLVLNSCGI 60
TCAGDEKEIA AFCAHVSELD LSDNKLEDWH EVSKIVSNVP QLEFLNLSSN PLNLSVLERT 120
CAGSFSGVRK LVLNNSKASW ETVHMILQEL PDLEELFLCL NDYETVSCPS ICCHSLKLLH 180
ITDNNLQDWT EIRKLGVMFP SLDTLVLANN HLNAIEEPDD SLARLFPNLR SISLHKSGLQ 240
SWEDIDKLNS FPKLEEVRLL GIPLLQPYTT EERRKLVIAR LPSVSKLNGS VVTDGEREDS 300
ERFFIRYYVD VPQEEVPFRY HELITKYGKL EPLAEVDLRP QSSAKVEVHF NDQVEEMSIR 360
LDQTVAELKK QLKTLVQLPT SNMLLYYFDH EAPFGPEEMK YSSRALHSFG IRDGDKIYVE 420
SKTK 424 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. 
Interpro
 IPR019955; Ubiquitin_supergroup. 
Pfam
  
SMART
  
PROSITE
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 
PRINTS