UniProt Accession

 SUHW_DROME; P08970; Q0KI74; Q9VFK9 

Genbank Protein ID

 Y00228; AE014297; BT003273 

Genbank Nucleotide ID

 CAA68371.1; AAF55044.1; AAO25030.1 

Protein Name

 Protein suppressor of hairy wing 

Protein Synonyms/Alias

  

Gene Name

 su(Hw) 

Gene Synonyms/Alias

 CG8573 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
101	APAASTVKILNEKKT	acetylation	[1]
591	SSMRSAVKIMERTDC	acetylation	[1]
916	EKKEIVGKAVDKDNS	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190. 

Sequence Annotation

 ZN_FING 220 242 C2H2-type 1; atypical.
 ZN_FING 290 313 C2H2-type 2.
 ZN_FING 319 341 C2H2-type 3; atypical.
 ZN_FING 348 366 C2H2-type 4.
 ZN_FING 380 402 C2H2-type 5.
 ZN_FING 413 435 C2H2-type 6.
 ZN_FING 441 463 C2H2-type 7.
 ZN_FING 469 491 C2H2-type 8.
 ZN_FING 497 519 C2H2-type 9.
 ZN_FING 523 545 C2H2-type 10.
 ZN_FING 553 577 C2H2-type 11.
 ZN_FING 596 619 C2H2-type 12.
 REGION 760 860 Interaction with mod(mdg4).
 MOD_RES 186 186 Phosphothreonine.  

Keyword

 Chromatin regulator; Chromosome; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 941 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005700; C:polytene chromosome; IDA:FlyBase.
 GO:0043035; F:chromatin insulator sequence binding; IDA:FlyBase.
 GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0031936; P:negative regulation of chromatin silencing; IMP:FlyBase.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IMP:UniProtKB. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00096; zf-C2H2 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS