UniProt Accession

 DERL2_MOUSE; Q8BNI4; Q920I5; Q99J12 

Genbank Protein ID

 AF208064; AK048627; AK077659; AK082564; AK083632; BC005682 

Genbank Nucleotide ID

 AAL14868.1; BAC33399.1; BAC36934.1; BAC38533.1; BAC38974.1; AAH05682.1 

Protein Name

 Derlin-2 

Protein Synonyms/Alias

 Degradation in endoplasmic reticulum protein 2; Der1-like protein 2; F-LANa 

Gene Name

 Derl2 

Gene Synonyms/Alias

 Der2; Flana 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
200	PGGIRILKTPSILRT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity). 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Unfolded protein response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 239 AA 

Protein Sequence

Gene Ontology

 GO:0005769; C:early endosome; IDA:MGI.
 GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0005770; C:late endosome; IDA:MGI.
 GO:0030968; P:endoplasmic reticulum unfolded protein response; ISS:UniProtKB.
 GO:0030433; P:ER-associated protein catabolic process; ISS:UniProtKB.
 GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO:0030970; P:retrograde protein transport, ER to cytosol; ISS:UniProtKB.
 GO:0001967; P:suckling behavior; IMP:MGI. 

Interpro

 IPR007599; DER1. 

Pfam

 PF04511; DER1 

SMART

  

PROSITE

  

PRINTS